胰腺癌患者乙型肝炎病毒感染的预防介入治疗与生存率分析

发布时间：2018-03-08 13:30

本文选题：乙型肝炎　切入点：胰腺癌　出处：《中华医院感染学杂志》2015年14期 　论文类型：期刊论文

【摘要】：目的研究胰腺癌患者乙型肝炎病毒感染行介入治疗的疗效及生存率。方法选择2011年5月-2014年1月收治的94例胰腺癌合并乙型肝炎患者,按照入院顺序将患者分为观察组和对照组各47例,对照组患者给予手术治疗,观察组患者则采取介入治疗,依据实体瘤的疗效评价标准(RECIST)对两组患者治疗之后的疗效进行比较分析,检测两组患者在治疗后的免疫抑制酸性蛋白(IAP)和可溶性肿瘤坏死因子受体Ⅳ(sTNFR-Ⅳ)的情况,比较两组患者治疗后的生存率。结果患者治疗疗效率观察组为78.72%、对照组为48.94%,两组比较差异有统计学意义(P0.05);治疗后观察组患者的IAP和sTNFR-IV水平显著低于对照组,差异有统计学意义(P0.05);治疗2、5、10个月后两组患者的HBV-DNA水平明显下降,且观察组显著低于对照组,差异有统计学意义(P0.05);观察组患者在6个月的生存率为95.74%,显著高于对照组,差异有统计学意义(P0.05)。结论胰腺癌合并乙型肝炎患者行介入治疗之后其疗效较好,具有较高的生存率。
[Abstract]:Objective to study the curative effect and survival rate of pancreatic cancer with interventional treatment in patients with hepatitis B virus infection. Methods in May 2011 94 cases with pancreatic cancer and hepatitis B patients with -2014 admitted in January, according to the order of admission were divided into observation group and control group with 47 cases in each group, the control group were treated with surgical treatment, patients in the observation group was taken to intervene on the basis of treatment, solid tumor efficacy evaluation criteria (RECIST) to compare and analyze the curative effect after treatment of the two groups, two groups were detected in immune after treatment of immunosuppressive acidic protein (IAP) and soluble tumor necrosis factor receptor IV (sTNFR- IV) cases, the survival rate of two groups were compared after treatment. Patients with treatment efficiency was 78.72% in the observation group, the control group was 48.94%, there was significant difference between two groups (P0.05); after treatment, the observation group of patients with IAP and sTNFR-IV were significantly lower than the control group, difference There was a significant correlation (P0.05); the HBV-DNA level of two groups of patients 2,5,10 months after treatment decreased significantly, and the observation group was significantly lower than the control group, the difference was statistically significant (P0.05); the patients in observation group were 6 months survival rate was 95.74%, significantly higher than the control group, the difference was statistically significant (P0.05). For patients with hepatitis B conclusion pancreatic cancer Interventional therapy after its curative effect is better, the survival rate is high.

【作者单位】：郑州大学附属肿瘤医院介入科;
【基金】：河南省科技厅研究基金资助项目(HNKJ78245-024)
【分类号】：R735.9;R512.62

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