双歧杆菌三联活菌胶囊对幽门螺旋杆菌感染的消化性胃溃疡的临床疗效研究

发布时间：2018-03-10 00:09

本文选题：消化性溃疡　切入点：幽门螺旋杆菌　出处：《中华医院感染学杂志》2017年19期 　论文类型：期刊论文

【摘要】：目的分析双歧杆菌三联活菌胶囊治疗消化性胃溃疡的临床疗效。方法选取医院2014年12月-2016年12月收诊的幽门螺旋杆菌(Hp)感染消化性胃溃疡患者593例为研究对象。随机分为常规治疗组306例,联合治疗组287例,常规治疗组采用传统三联疗法,联合治疗组采用双歧杆菌三联活菌胶囊治疗。记录治疗前后两组患者的胃液pH、静脉血降钙素原、白细胞介素8和肿瘤坏死因子α的变化,治疗后进行胃镜检查溃疡愈合情况并统计不良反应,再次进行13 C尿素呼气试验检测Hp根除率。结果治疗前,两组胃液pH、静脉血降钙素原、白细胞介素8和肿瘤坏死因子α水平无显著差异,常规组治疗后胃液pH为(4.62±0.70),显著低于联合治疗组(6.37±0.95),静脉血降钙素原、白细胞介素8和肿瘤坏死因子α水平分别为(43.57±14.17)mg/L、(49.29±16.74)μg/L和(38.22±22.06)ng/L显著高于联合治疗组(26.76±8.21)mg/L、(24.67±9.48)μg/L和(27.35±12.60)ng/L(P均0.05);常规治疗组治愈率为35.62%显著低于联合治疗组60.98%(P0.05);常规治疗组患者的严重不良反应发生率为4.58%显著高于联合治疗组2.44%(P0.05);常规治疗组的根除率为38.56%显著低于联合治疗组82.23%(P0.05)。结论使用双歧杆菌三联活菌胶囊治疗Hp感染的消化性胃溃疡,不良反应发生率低,临床疗效和根除率明显优于传统的三联疗法。
[Abstract]:Objective to analyze the clinical effect of Bifidobacterium triple active bacilli capsule in the treatment of peptic ulcer. Methods 593 patients with peptic ulcer infected by Helicobacter pylori were selected from December 2014 to December 2016 in our hospital. They were randomly divided into routine treatment group (306 cases), 287 patients in the combined treatment group were treated with traditional triple therapy and the combined treatment group were treated with Bifidobacterium triple viable capsule. The pH of gastric juice and procalcitonin in venous blood were recorded before and after treatment in both groups. The changes of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF- 伪), the ulcer healing and adverse reactions were examined by gastroscopy after treatment, and the HP eradication rate was detected by 13 C urea breath test again. There was no significant difference in pH, procalcitonin, interleukin-8 and tumor necrosis factor 伪 between the two groups. After treatment, the pH of gastric juice in the routine group was 4.62 卤0.70, which was significantly lower than that in the combined treatment group (6.37 卤0.95). The levels of interleukin 8 and tumor necrosis factor 伪 were 43.57 卤14.17 mg / L and 49.29 卤16.74 渭 g / L and 38.22 卤22.06 渭 g / L, respectively, which were significantly higher than those in the combined treatment group (26.76 卤8.21 mg / L, 24.67 卤9.48) 渭 g / L and 27.35 卤12.60 ng / L / L, respectively. The cure rate in the routine treatment group was significantly lower than that in the combined treatment group (60.98g / L vs 60.98g / L). The incidence rate of 4.58% was significantly higher than that of the combined treatment group (2.44) and the eradication rate of the routine treatment group was 38.56% significantly lower than that of the combined treatment group (82.23) P0.05.Conclusion the peptic ulcer of HP infection was treated with Bifidobacterium triple live bacillus capsule. The incidence of adverse reactions was low, and the clinical efficacy and eradication rate were significantly better than the traditional triple therapy.
【作者单位】：佛山市三水区人民医院消化内科;
【基金】：国家自然科学基金资助项目(30271567)
【分类号】：R573.1

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