胃食管反流病与阻塞型睡眠呼吸暂停低通气综合征的关系

发布时间：2018-03-10 13:15

本文选题：胃食管反流病　切入点：睡眠呼吸暂停低通气综合征　出处：《宁夏医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的研究调查胃食管反流病（GERD）与阻塞型睡眠呼吸暂停低通气综合征(OSAHS)的关系。材料与方法收集260例OSAHS患者，其中男性194例、女性66例，对所收集的患者进行胃食管反流病问卷调查，分为伴有GERD组119例，无GERD组141例，对伴有GERD组和无GERD组的患者进行睡眠呼吸暂停低通气指数（AHI）、体重指数（BMI）的比较。同时对不同分度的OSAHA患者进行胃食管反流症状积分的比较。研究结果260例OSAHS患者中伴有GERD组患者为119例，约占45.77%（119/260），不伴有GERD组患者为141例，约占54.23%（141/260）；伴有GERD组中男性99例(83.19%)，女性20例(16.80%)，不伴有GERD组男性95例(67.38%)，女性46例(32.62%)，伴有GERD组与不伴有GERD组在性别方面有统计学意义(χ2=8.524，，P=0.004)；伴有GERD的OSAHS患者中，以年龄大于47岁患者为主，占78.1%；同时伴有GERD组的OSAHS患者比无GERD组的OSAHS患者的体重指数（BMI）及睡眠呼吸暂停低通气指数（AHI）均高，P＜0.05，提示结果有统计学意义；不同分度的OSAHS患者中，重度OSAHS患者的GERD积分较中度OSAHS患者高，中度OSAHS患者的GERD积分较轻度OSAHS患者高，P＜0.05，结果具有统计学意义。结论1.伴有GERD的OSAHS患者以中老年、肥胖男性居多； 2. OSAHS患者中GERD的发病比例较高，约占45.77%； 3．在OSAHS患者中，伴有GERD组的睡眠呼吸暂停指数（AHI）较不伴有GERD组患者高； 4.不同分度的OSAHS患者随着病情的严重程度增加，其GERD积分也加重，二者成正相关。
[Abstract]:Objective to investigate the relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea hypopnea syndrome (OSAHS). Materials and methods 260 patients with OSAHS, including 194 males and 66 females, were investigated with gastroesophageal reflux disease (GERD). The patients were divided into GERD group (119 cases) and no GERD group (141 cases). The apnea hypopnea index (AHI) and body mass index (BMI) were compared between the patients with GERD and those without GERD. The scores of gastroesophageal reflux symptoms were compared among OSAHA patients with different degrees of OSAHA. Results among the 260 patients with OSAHS, 119 were in the GERD group, accounting for 45.77% of 119 / 260 cases, and 141 cases in the non-#en2# group. In the GERD group, there were 99 males (83.19%), 20 females (16.80%), 95 males in the GERD group (67.3838), 46 females (32.62%), and there were significant differences in sex between the GERD group and the GERD group (蠂 28.524 P 0.004; in OSAHS patients with GERD, the majority were older than 47 years old). At the same time, the body mass index (BMI) and sleep apnea hypopnea index (AHII) in OSAHS patients with GERD were significantly higher than those in OSAHS patients without GERD (P < 0.05). The GERD score of severe OSAHS patients was higher than that of moderate OSAHS patients, and the GERD score of moderate OSAHS patients was higher than that of mild OSAHS patients (P < 0.05). Conclusion 1. The middle and old age patients with OSAHS with GERD are mostly obese men. 2. 2. The incidence of GERD was higher in OSAHS patients, accounting for 45.77%. 3. In OSAHS patients, the sleep apnea index (AHII) in GERD group was higher than that in non-#en2# group. 4. The GERD score of OSAHS patients with different grades increased with the severity of the disease, which was positively correlated with the severity of the disease.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R571

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