抗病原性真菌药物与肠道微生态失衡关联分析

发布时间：2018-03-14 01:07

本文选题：抗病原性真菌　切入点：肠道　出处：《科技通报》2015年10期 　论文类型：期刊论文

【摘要】：目的:研究一种采用抗病原性真菌药物治疗的方法,实现对肠道微生态失衡的诊疗和关联性问题分析,为临床消化内科和肠道疾病提供依据。方法:基于概率分布特性,检验水准α=0.05认为合理,得到抗病原性真菌的I型含有Cag A和Vac A基因并表达两种蛋白,患者肠道功能低下时,对影响肠道TSH进行抑制,用表面活性剂溶解蛋白脂质体,在提取的肠道功能测定样本中进行微生态失衡关联分析。结果:采取配对t检验,得到抗病原性真菌的活性相当于变形杆菌的400倍,将阳性抗病原性真菌分离物质采集样本梯度稀释为10倍、100倍、150倍、250倍、500倍、1000倍按照上述检测步骤进行操作,抗病原性真菌检测p H在6.5~7.8范围,肠道微生态失衡者的外周血白细胞计数4×109/L,肠道微生态失衡者的外周血白细胞计数10×109/L,有效抑制了肠道微生态失衡。结论:采用该方法能有效实现对肠道微生态失衡抑制,实现定量分析,对预防和治疗肠道疾病具有重要的临床价值。
[Abstract]:Objective: To study a method against pathogenic fungi of drug treatment, analysis of intestinal microflora imbalance in the treatment and associated problem, provide the basis for clinical gastroenterology and gastrointestinal diseases. Methods: the probability distribution based on a =0.05 level test that is reasonable, be against pathogenic fungi I Cag and A Vac and A gene contains two proteins, intestinal function in patients with low, to suppress the effects of intestinal TSH, surfactant protein dissolved liposomes, determination of sample in micro ecological imbalance correlation analysis in the extraction of intestinal function. Results: the paired t test, obtained against pathogenic fungi activity is equivalent to 400 times of Proteus, positive anti pathogenic fungi isolated from material samples dilution of 10 times, 100 times, 150 times, 250 times, 500 times, 1000 times in accordance with the above detection steps, against pathogenic fungi. P H is in the range of 6.5~7.8, peripheral white blood cell count of intestinal micro ecological imbalance of 4 x 109/L, peripheral white blood cell count of intestinal micro ecological imbalance of 10 * 109/L, can effectively inhibit intestinal Dysbiosis. Conclusion: the method can effectively realize the intestinal micro ecological imbalance suppression, implementation quantitative analysis has important clinical value for the prevention and treatment of intestinal diseases.

【作者单位】：新乡医学院微生物学教研室;
【分类号】：R57

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