甘草酸二铵治疗急性药物性肝损伤临床分析

发布时间：2018-03-21 03:09

本文选题：甘草酸二铵　切入点：急性药物性肝损伤　出处：《中国地方病防治杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的对甘草酸二铵应用于急性药物性肝损伤临床治疗中的效果进行分析。方法选取120例2014年9月-2016年10月期间在我院接受治疗的急性药物性肝损伤患者,1∶1随机分为参照组(接受门冬氨酸钾镁治疗)和实验组(接受甘草酸二铵治疗)各60例,对两种不同药物的治疗效果进行对照研究。结果就治疗显效率和治疗总有效率而言,实验组患者均明显高于参照组[68.33%、91.67%vs.36.67%、71.67%];就血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血清碱性磷酸酶、血清总胆红素等指标复查时间而言,实验组患者均明显短于参照组(P0.05),组间差异具有统计学意义。结论甘草酸二铵应用于急性药物性肝损伤临床治疗中的效果十分理想,在控制病情、提高治疗效果、缩短病程、改善肝功能以及提高生命质量等方面具有极其显著的优势,值得大力推广。
[Abstract]:Objective to analyze the clinical effect of diammonium glycyrrhizinate in the treatment of acute drug-induced liver injury. Methods 120 patients with acute drug-induced liver injury received treatment in our hospital from September 2014 to October 2016 were randomly divided into 1: 1 randomly. There were 60 cases in the control group (treated with potassium magnesium aspartate) and 60 cases in the experimental group (treated with diammonium glycyrrhizinate). Results in terms of the effective rate of treatment and the total effective rate of treatment, the patients in the experimental group were significantly higher than those in the reference group [68.33] 91.67 vs.36.67%, and in the case of serum alanine aminotransferase, aspartate aminotransferase, aspartate aminotransferase, In terms of serum alkaline phosphatase, serum total bilirubin and so on, Conclusion the effect of diammonium glycyrrhizinate in the treatment of acute drug-induced liver injury is very satisfactory, which can control the disease, improve the therapeutic effect and shorten the course of disease. The improvement of liver function and the improvement of quality of life and so on has the extremely remarkable superiority, is worth vigorously popularizing.
【作者单位】：吉林市传染病医院;吉林省地方病第二防治研究所;
【分类号】：R575

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