加味增液承气汤灌肠治疗急性肠功能衰竭的临床研究

发布时间：2018-03-22 17:40

本文选题：急性肠功能衰竭　切入点：加味增液承气汤　出处：《青岛大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：对加味增液承气汤灌肠治疗急性肠功能衰竭的临床疗效进行初步探讨研究,旨在为急性肠功能衰竭的中医临床治疗提供一定参考。方法：选择我科室于2013年1-12月期间收治的48例急性肠功能衰竭患者作为本研究对象,将其按数字随机原则分为治疗组与对照组各24例,所有患者在入院后均常规治疗原发病,并给予对症支持治疗,治疗组治疗方法在此基础上再加行加味增液承气汤水煎液灌肠治疗,观察并记录两组患者在接受治疗后的首次排便时间、腹痛腹胀缓解时间、肠鸣音恢复时间以及住院时间等,另分别于治疗前与治疗后7d考察患者的急性生理与慢性健康状况评分Ⅱ(APACHE Ⅱ评分)以及相关炎症反应指标白细胞计数(WBC)与血清C-反应蛋白(CRP)。结果：治疗组与对照组在性别、年龄、治疗前APACHE Ⅱ评分方面均无显著性差异(P0.05)；组间比较治疗前炎症反应指标也无统计学意义(twBC=0.814, PWBC=0.2060.05; tCRP=0.887, PCRP=0.2010.05),两组患者具可比性；治疗后比较两组患者的首次排便时间、腹痛腹胀缓解时间、肠鸣音恢复时间以及住院时间均以观察组显著更短,与对照组比较均有统计学意义(P0.05)；治疗前两组患者APACHEII评分比较无统计学意义(P0.05),治疗后7d治疗组APACHE Ⅱ评分显著低于对照组(P0.01)；治疗过程中治疗组与对照组少数病例出现轻微腹泻,但不影响用药,此外无其他明显任何不良反应出现。结论：加味增液承气汤灌肠治疗急性肠功能衰竭不仅可显著地缩短患者的首次排便时间、腹痛腹胀缓解时间、肠鸣音恢复时间以及住院时间,同时也可显著降低APACHE Ⅱ评分,临床疗效满意,建议进一步开展大宗病例的临床研究。
[Abstract]:Objective: To investigate the clinical efficacy of Jiawei Zengli Chengqi Decoction enema in the treatment of acute intestinal failure, aiming to provide certain reference for clinical treatment of acute intestinal failure in TCM.
Methods: 48 cases of acute intestinal failure patients in our department treated during 2013 1-12 months as the research object, according to its figures were randomly divided into treatment group and control group of 24 cases, all patients in the hospital were the routine treatment of the primary disease, and given symptomatic treatment, the treatment group based method then by Jiaweizengyechengqi Decoction Decoction enema, observe and record the two groups of patients after treatment of the first defecation time, abdominal pain relief time, bowel sound recovery time and hospital stay, the other respectively before and after the treatment of 7D patients with acute physiology and chronic health evaluation II (APACHE score) and related indicators of inflammation of white blood cell count (WBC) with the serum C- reactive protein (CRP).
Results: the treatment group and control group in gender, age, before treatment APACHE score showed no significant difference (P0.05); the treatment group compared with no significant inflammatory reaction index (twBC=0.814, PWBC=0.2060.05; tCRP=0.887, PCRP=0.2010.05), the two groups were comparable; after treatment were compared between the two groups the first defecation time, abdominal pain relief time, bowel sound recovery time and hospitalization time was significantly shorter in the observation group, and control group were statistically significant (P0.05); two groups of patients before treatment APACHEII score was not statistically significant (P0.05), 7d treatment group after treatment APACHE score was significantly lower than the control group (P0.01) in the course of treatment; the treatment group and the control group a few cases had mild diarrhea, but does not affect the use, in addition there is no other obvious any adverse reactions.
Conclusion: Jiaweizengyechengqi Decoction enema in the treatment of acute intestinal failure not only can significantly shorten the patient's first defecation time, abdominal pain relief time, bowel sound recovery time and hospitalization time, but also can significantly reduce APACHE score, clinical efficacy, clinical studies suggest that further development of the bulk of cases.

【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574

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