急性胰腺炎患者血清Ghrelin、LXA4水平变化及临床意义

发布时间：2018-03-22 22:20

本文选题：急性胰腺炎　切入点：生长激素释放肽　出处：《山东医药》2017年24期 　论文类型：期刊论文

【摘要】：目的探讨急性胰腺炎(AP)患者血清生长激素释放肽(Ghrelin)、脂氧素A4(LXA4)水平变化及其临床意义。方法选择AP患者120例,其中轻症54例(轻症AP组)、重症66例(重症AP组),住院期间死亡12例(均为重症AP);另选体检健康者60例为对照组。采用ELISA法检测血清Ghrelin、LXA4,采用受试者工作特征(ROC)曲线分析血清Ghrelin、LXA4对AP的诊断价值。结果轻、重症AP组治疗前血清Ghrelin水平均高于对照组,重症AP组高于轻症AP组;LXA4水平均低于对照组,重症AP组低于轻症AP组;治疗第3、5、7天,轻、重症AP组血清Ghrelin水平呈逐渐降低趋势,血清LXA4水平呈逐渐升高趋势,重症AP组变化更明显;组间及组内比较P均0.05。住院期间死亡的AP患者入院时血清Ghrelin水平高于、LXA4水平低于存活者(P均0.01)。血清Ghrelin诊断AP的ROC曲线下面积(AUC)为0.710,敏感性为76.3%,特异性为85.5%,准确性为80.4%;血清LXA4诊断AP的AUC为0.728,敏感性为70.8%,特异性为89.2%,准确性为88.2%。结论 AP患者血清Ghrelin水平升高、LXA4水平降低;检测二者水平变化有助于AP诊断、病情判断及患者预后评估。
[Abstract]:Objective to investigate the changes and clinical significance of serum growth hormone releasing peptide (ghrelin) and lipoxygenin A _ 4 (LXA4) in patients with acute pancreatitis (AP). Methods 120 patients with AP were selected. 54 cases of mild disease (mild AP group, 66 cases of severe disease (severe AP group, 12 cases of death in hospital; 60 cases of health check group as control group). Serum ghrelin LXA4 was detected by ELISA method, and the operating characteristics of subjects were used to detect the serum ghrelin LXA4. The diagnostic value of serum ghrelin LXA4 in AP was mild. The level of serum Ghrelin in severe AP group was higher than that in control group before treatment, the level of serum Ghrelin in severe AP group was lower than that in mild AP group, and that in severe AP group was lower than that in mild AP group. The level of serum LXA4 increased gradually, especially in severe AP group. The serum Ghrelin level of AP patients who died during hospitalization was higher than that of survivors (P < 0.01). The area under ROC curve of serum Ghrelin diagnosis of AP was 0.710, the sensitivity was 76.3and the specificity was 85.5. The AUC, sensitivity, specificity and accuracy of serum LXA4 in the diagnosis of AP were 0.728, 88.2 and 88.2.Conclusion the level of serum Ghrelin in AP patients increased and the level of LXA4 decreased. Detection of both levels is helpful for AP diagnosis, diagnosis and prognostic evaluation.
【作者单位】：山东医学高等专科学校;山东省立医院;
【基金】：山东省教育厅科研资助课题(J09LF29)
【分类号】：R576

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