肝硬化患者肺部感染的相关因素分析

发布时间：2018-03-24 05:00

本文选题：肝硬化患者　切入点：肺部感染　出处：《中国病原生物学杂志》2017年01期

【摘要】：目的分析肝硬化患者发生肺部感染的相关因素,为临床治疗提供依据。方法收集感染患者的一般资料、腹水情况、病原菌感染、基础疾病、抗菌药物使用情况等。用SPSS15.0进行统计分析,采用χ2检验分析肝硬化患者发生肺部感染的相关因素。结果 1 184例肝硬化患者中出现肺部感染142例,感染率为11.99%,其中男性95例,女性47例;乙肝性肝硬化98例,乙醇性肝硬化24例,原发性胆汁性肝硬化10例。142例肺部感染肝硬化患者痰液标本中检出病原菌157株,其中大肠埃希菌46株,肺炎克雷伯菌27株,金黄色葡萄球菌22株,铜绿假单胞菌14株,表皮葡萄球菌13株,肺炎链球菌11株,白色假丝酵母菌9株,其他病原菌15株。142例肝硬化肺部感染患者发生肺部感染常伴有不同的临床特征,其中发热患者占19.01%,肺部浸润患者占14.79%。肝硬化患者的性别和腹水有无情况与感染发生无关,差异无统计学意义(P均0.05);而肝硬化患者的年龄、住院时间、基础疾病有无、使用抗菌药物是否合理、是否接受侵入性操作与其肺部感染发生相关,差异有统计学意义(P均0.05)。结论不同类型的肝硬化患者均有肺部感染发生,患者感染病原菌类型以革兰阴性为主。感染患者常伴有发热、肺部浸润、呼吸衰竭等临床症状,且感染发生与年龄、住院时间、基础疾病、使用抗菌药物以及侵入性操作相关。
[Abstract]:Objective to analyze the related factors of pulmonary infection in patients with liver cirrhosis and to provide evidence for clinical treatment. Methods the general data of infected patients, ascites, pathogenic bacteria infection and underlying diseases were collected. The use of antimicrobial agents was analyzed by SPSS15.0 and 蠂 2 test was used to analyze the related factors of pulmonary infection in patients with liver cirrhosis. Results 142 cases of pulmonary infection were found in 1 184 patients with liver cirrhosis, the infection rate was 11.99%, 95 cases of them were male. 47 cases were female, 98 cases were hepatitis B cirrhosis, 24 cases were ethanol cirrhosis, 10 cases were primary biliary cirrhosis. 157 strains of pathogenic bacteria were found in sputum of 10 cases of primary biliary cirrhosis. 46 strains of Escherichia coli and 27 strains of Klebsiella pneumoniae were detected. There were 22 strains of Staphylococcus aureus, 14 strains of Pseudomonas aeruginosa, 13 strains of Staphylococcus epidermidis, 11 strains of Streptococcus pneumoniae, 9 strains of Candida albicans. 15 strains of other pathogens. 142 patients with pulmonary infection of liver cirrhosis often accompanied with different clinical characteristics, in which fever patients accounted for 19.01, pulmonary infiltration patients accounted for 14.79.The sex and ascites of patients with cirrhosis have no relationship with the occurrence of infection. There was no significant difference between the two groups (P < 0.05), but the age, length of stay, basic diseases, rational use of antimicrobial agents and acceptance of invasive procedures were related to the occurrence of pulmonary infection in patients with liver cirrhosis. Conclusion Pulmonary infection occurs in patients with different types of liver cirrhosis, and Gram-negative is the main pathogen of infection. Patients with infection are often accompanied with fever, pulmonary infiltration, respiratory failure and other clinical symptoms. Infection is associated with age, length of stay, underlying diseases, use of antimicrobial agents, and invasive procedures.
【作者单位】：贵州省凯里市第一人民医院重症医学科;贵州省凯里市第一人民医院检验科;贵州省思南县人民医院心电图室;
【分类号】：R575.2;R563.1

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