肠脂肪酸结合蛋白、组氨酸脱羧酶和二胺氧化酶在绞窄性肠梗阻诊断中的意义

发布时间：2018-03-26 21:36

  本文选题：肠脂肪酸结合蛋白　切入点：组氨酸脱羧酶　出处：《东南大学学报(医学版)》2017年06期

【摘要】：目的:探讨肠脂肪酸结合蛋白(IFABP)、组氨酸脱羧酶(HDC)和二胺氧化酶(DAO)在绞窄性肠梗阻诊断中的意义。方法:选择120例肠梗阻患者作为研究对象,其中绞窄性肠梗阻58例,单纯性肠梗阻62例,并且选取同期健康对照者60例,检测所有研究对象血清中IFABP、HDC和DAO的含量。结果:入院时血清IFABP、HDC和DAO含量绞窄性肠梗阻组均明显高于单纯性肠梗阻组;治疗后同时间点血清IFABP、HDC和DAO含量绞窄性肠梗阻组均高于单纯性肠梗阻组,差异均有统计学意义(均P0.05)。绞窄性肠梗阻组血清IFABP、HDC和DAO含量随着治疗时间的延长而呈增高趋势,并且各时间点之间差异有统计学意义(均P0.05);工作特征曲线下面积(AUC)值HDC高于FABP和DAO(分别为0.914、0.878、0.874),当HDC的临界值为30.00 ng·ml~(-1)时,诊断绞窄性肠梗阻的灵敏度为74.03%,特异度为94.00%,假阴性率为25.12%,假阳性率为5.00%,HDC对绞窄性肠梗阻的诊断价值明显优于IFABP和DAO。结论:IFABP、HDC和DAO可作为绞窄性肠梗阻的诊断指标,HDC的诊断价值优于IFABP和DAO。
[Abstract]:Objective: to investigate the significance of intestinal fatty acid binding protein (IFABP), histidine decarboxylase (HDC) and diamine oxidase (diamine oxidase) in the diagnosis of strangulated intestinal obstruction. Methods: 120 patients with intestinal obstruction were selected as study subjects, including 58 patients with strangulated intestinal obstruction. 62 cases of simple intestinal obstruction and 60 cases of healthy control were selected to detect the contents of HDC and DAO in the serum of all the subjects. Results: the contents of HDC and DAO in serum of patients with simple intestinal obstruction were significantly higher than those of patients with simple intestinal obstruction at admission. At the same time after treatment, the levels of HDC and DAO in serum of strangulated intestinal obstruction group were higher than those in simple intestinal obstruction group, and the difference was statistically significant (P 0.05). The serum levels of IFABP HDC and DAO in strangulated intestinal obstruction group increased with the prolongation of treatment time. And there were significant differences among different time points (all P 0.05; area under working characteristic curve) HDC was higher than that of FABP and Dao (0.914 卤0.878 卤0.874g, respectively), and when the critical value of HDC was 30.00 ng / ml ~ (-1), The sensitivity, specificity, false negative rate, false positive rate and false positive rate in diagnosis of strangulated intestinal obstruction were 74.03 and 94.00, 25.12 and 5.00, respectively. Conclusion the diagnostic value of IFABP and DAO can be used as diagnostic index of strangulated intestinal obstruction. The diagnostic value of IFABP and Dao was superior to that of Dao.
【作者单位】： 鄂州职业大学医学院普外科;
【分类号】：R574.2
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本文编号：1669726