声辐射力脉冲技术和天门冬氨酸氨基转移酶与血小板比值指数评价家兔肝纤维化

发布时间：2018-03-27 07:34

  本文选题：声辐射力脉冲成像　切入点：肝纤维化　出处：《兰州大学》2014年硕士论文

【摘要】：目的探讨声辐射力脉冲(ARFI)技术和天门冬氨酸氨基转移酶与血小板比值指数(APRI)评价家兔肝纤维化模型的诊断价值。 方法应用硫代乙酰胺(TAA)对32只家兔以皮下注射的方法建立肝纤维化模型,8只家兔作为对照组。于首次注射后第4、8、12周分批应用ARFI获取剪切波速度(SWV),计算APRI,取其肝脏行病理肝纤维化分期。以病理检查结果为金标准,比较SWV和APRI指数对家兔肝纤维化分期的诊断价值。 结果共29只家兔造模成功,其中肝纤维化分期为S1、S2、S3和S4期的分别有10、8、7和4只。SWV值和APRI均随纤维化程度的加重而增高(P＜0.05)。SWV (r=0.724, P0.05)和APRI指数(r=0.555,P＜0.05)与肝纤维化病理分级均存在相关性。SWV和APRI诊断家兔肝纤维化S≥1、S≥2、S≥3、S=4的ROC曲线下面积分别为0.92、0.81,0.87、0.78,0.82、0.76,0.89、0.79。SWV和APRI联合诊断S≥3的AUC为0.84,敏感度为81.80%,特异度为73.10%,阳性预测值为56.23%,阴性预测值为90.48%。 结论ARFI技术与APRI可以定量评估家兔肝纤维化程度,以ARFI技术的价值较高。
[Abstract]:Objective to evaluate the diagnostic value of acoustic radiation pulse ARFI (ARFI) technique and aspartate aminotransferase / platelet ratio index (APRI) in the diagnosis of hepatic fibrosis in rabbits. Methods Hepatic fibrosis model was established in 32 rabbits by subcutaneous injection of acetamide thioacetamide (TAA) as control group. Shear wave velocities were obtained by ARFI in batches at the 4th week of the 8th week after the first injection. Pathological hepatic fibrosis stages were performed in the viscera. The results of pathological examination were taken as the gold standard. To compare the diagnostic value of SWV and APRI index in the stage of hepatic fibrosis in rabbits. Results A total of 29 rabbits were successfully established. Among them, the hepatic fibrosis stage of S1 / S2 / S3 and S4 were 10 / 8 / 7 and 4, respectively. SWV and APRI increased with the severity of fibrosis (P < 0. 05, P < 0. 05) and the APRI index was 0. 555 (P < 0. 05). SWV and APRI were correlated with the pathological grade of hepatic fibrosis in rabbits (P < 0. 05). The area under the ROC curve of S 鈮，

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