声辐射力脉冲弹性成像技术评估大鼠非酒精性脂肪肝及肝纤维化

发布时间：2018-03-29 11:05

  本文选题：声辐射力脉冲　切入点：弹性成像技术　出处：《中国医学影像技术》2017年09期

【摘要】：目的探讨利用声辐射力脉冲成像(ARFI)技术评估大鼠肝脏非酒精性脂肪肝(NAFLD)及肝纤维化的价值。方法通过喂养高脂食物建立不同阶段NAFLD大鼠模型。解剖大鼠,取右叶肝脏嵌入明胶仿体内用于ARFI检查,测量大鼠肝脏剪切波速度(SWV),将其余肝组织用于组织学评估,并根据NAFLD活动性评分(NAS),将大鼠分为正常组(NAS=0),单纯性脂肪肝(SS)组(1≤NAS≤2),边界组(3≤NAS≤4)、非酒精性脂肪性肝炎(NASH)组(NAS≥5)。通过ROC曲线分析评估ARFI判断不同程度NAFLD及肝纤维化的能力。结果正常组、SS组、边界组、NASH组间SWV值总体差异有统计学意义(F=31.53,P0.001)。以SWV值≥2.54m/s鉴别正常组与SS组、以SWV值≥2.90m/s鉴别SS组与NASH组,对应的ROC曲线下面积(AUC)分别为0.922[95%CI(0.871,0.973),P0.001]、0.882[95%CI(0.807,0.956),P0.001],敏感度分别为93.5%、83.3%,特异度分别为100%、84.2%。以SWV值≥3.48m/s诊断≥F2期肝纤维化、以SWV值≥3.61m/s诊断≥F3期肝纤维化、以SWV值≥4.50m/s诊断肝硬化(F4期)的AUC分别为0.963[95%CI(0.909,1.000),P0.001]、0.997[95%CI(0.990,1.000),P0.001]、0.993[95%CI(0.982,1.000),P0.001],敏感度分别为92.9%、100%、100%,特异度分别为97.6%、98.9%、96.8%。结论 ARFI技术测量的SWV值可有效评估NAFLD及含有NAFLD的肝纤维化程度。
[Abstract]:Objective to evaluate the value of acoustic radiation pulse imaging (ARFI) technique in the assessment of nonalcoholic fatty liver (NAF LDD) and liver fibrosis in rats. Methods NAFLD rat models at different stages were established by feeding high-fat food. The right lobe liver was embedded in gelatin in vivo for ARFI examination. The shear wave velocity of rat liver was measured and the rest of liver tissue was used for histological evaluation. According to the activity score of NAFLD, the rats were divided into normal group, simple fatty liver group, simple fatty liver group, borderline group, NAS group and non-alcoholic hepatitis group respectively. ARFI was evaluated by ROC curve analysis. NAFLD and ability of hepatic fibrosis. Results normal group, SS group, There was significant difference in SWV value between the border group and Nash group. The SWV value 鈮，

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