维吾尔族与汉族结肠黑变病851例临床分析

发布时间：2018-03-29 15:29

  本文选题：结肠黑变病　切入点：性别　出处：《新疆医科大学》2015年硕士论文

【摘要】：目的：探讨新疆地区汉族和维吾尔族结肠黑变病(Melanosis Colon, MC)患者内镜下特征及其与性别、年龄、种族、结肠息肉、结肠恶性肿瘤之间的关系。方法：对2006年1月至2014年1月间行肠镜检出的851例汉族及维吾尔族MC患者的临床资料(患者性别、年龄、民族、主诉)、镜下表现、病理学检查及合并症等结果进行回顾性分析。与同期行肠镜检查的汉族及维吾尔族非MC患者的相关资料进行对比,比较两组之间是否有异同。结果：在44568例行肠镜检查的汉族及维吾尔族患者中发现851例结肠黑变病患者(1.91%),其中汉族472例,维吾尔族379例,男性264例,女性587例,平均年龄55.02±14.14岁,与同期非MC患者相比,年龄大于65岁、女性、维吾尔族更易发生结肠黑变病(P值均0.001)。851例MC患者中有便秘史者593例,使用泻剂者419例,其中315例使用过蒽醌类泻药。MC患者中最主要的临床表现是便秘,其次是腹痛和无症状体检。在黑变病的分布中,累及全结肠者663例(77.91%),其次为直肠乙状结肠79例(9.28%)；从黑变病严重程度来看,重度黑变病主要发生在横结肠(89例,10.45%),其次为降结肠和乙状结肠的交界处(71例,8.34%),直肠黑变病程度一般较轻。851例MC患者中合并结肠息肉者179例,合并结肠恶性肿瘤24例,与同期非MC组相比无统计学差异(P值分别为0.057,0.755)。结论：老年人及女性易患本病,维吾尔族中MC检出率高于汉族,提示遗传、种族可能是MC的发病原因之一,或与各地区饮食生活习惯相关。
[Abstract]:Objective: to investigate the endoscopic features and their association with sex, age, race and colonic polyps in patients with Melanosis colonization (MCG) of Han and Uygur in Xinjiang. Methods: the clinical data of 851 patients with MC of Han nationality and Uygur nationality (gender, age, nationality, chief complaint, under microscope) from January 2006 to January 2014 were analyzed. The results of pathological examination and complications were analyzed retrospectively. The results were compared with those of non-MC patients of Han and Uygur nationality who underwent enteroscopy at the same time. Results: 851 cases of colonic melanosis were found in 44568 cases of Han and Uygur patients, including 472 cases of Han nationality, 379 cases of Uygur nationality, 264 cases of male and 587 cases of female, with an average age of 55.02 卤14.14 years. Compared with the non-MC patients in the same period, 593 cases had constipation history and 419 cases were treated with cathartic agent, compared with non-MC patients in the same period, female and Uygur were more susceptible to colonic melanosis (P = 0.0010.851). Constipation was the main clinical manifestation of 315 patients who had used anthraquinone laxative .MC, followed by abdominal pain and asymptomatic physical examination. In 663 cases with total colon involvement, 77.91 cases were involved, followed by 79 cases of rectosigmoid colon and 9.28%. Judging from the severity of melanosis, Severe melanosis mainly occurred in 89 cases of transverse colonic carcinoma, followed by descending colon and sigmoid colon junction in 71 cases. The degree of rectal melanosis was generally mild .851 cases of MC patients had 179 cases of colonic polyps and 24 cases of malignant tumor of colon. There was no significant difference in P value between the non-MC group and the non-MC group in the same period. Conclusion: the prevalence rate of MC in the elderly and women is higher than that in the Han nationality, suggesting that heredity, race may be one of the causes of MC. Or related to eating and living habits in various regions.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R574.62
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本文编号：1681733