乳酸左氧氟沙星与头孢唑肟在急性水肿型胆源性胰腺炎抗感染治疗中的疗效对比

发布时间：2018-03-30 08:52

本文选题：急性胰腺炎　切入点：乳酸左氧氟沙星　出处：《第二军医大学学报》2015年07期

【摘要】：目的观察并对比乳酸左氧氟沙星/头孢唑肟在急性水肿型胆源性胰腺炎治疗中的效果,为急性胰腺炎的临床规范抗感染治疗提供参考。方法选取2014年1月至2014年11月期间在本院急诊科病区连续收治的180例急性水肿型胆源性胰腺炎患者,随机分为乳酸左氧氟沙星治疗组与头孢唑肟治疗组,在禁食水、胃肠减压、抑酸、抑酶、营养支持等常规治疗基础上分别选用乳酸左氧氟沙星及头孢唑肟抗感染,监测患者呕吐、腹痛、腹胀缓解情况及时间,开放饮食时间,住院天数,血常规、C反应蛋白(CRP)、生化、血清淀粉酶变化及影像学胰腺炎症吸收情况。结果乳酸左氧氟沙星治疗组总有效率高于头孢唑肟治疗组(P0.05);与头孢唑肟治疗组比较,乳酸左氧氟沙星治疗组呕吐、腹痛、腹胀缓解时间缩短(P0.01),开放饮食时间提前,住院天数缩短(P0.05),血常规、CRP及血淀粉酶恢复正常时间均提前(P0.05),影像学胰腺炎症吸收快(P0.05)。结论在急性水肿型胆源性胰腺炎抗感染治疗中,乳酸左氧氟沙星效果优于头孢唑肟。
[Abstract]:Objective to observe and compare the efficacy of levofloxacin lactate / cefazoxime in the treatment of acute edematous biliary pancreatitis. Methods from January 2014 to November 2014, 180 patients with acute edematous biliary pancreatitis were treated in the emergency department of our hospital from January 2014 to November 2014. Levofloxacin lactate group and cefazoxime group were randomly divided into two groups. Levofloxacin lactate and cefazoxime were used to fight infection on the basis of fasting water, gastrointestinal decompression, acid suppression, enzyme inhibition, nutritional support and so on. Patients with vomiting, abdominal pain, abdominal distension relief and time, open diet time, hospitalization days, blood routine C-reactive protein (CRP), biochemical, Results the total effective rate of levofloxacin lactate treatment group was higher than that of cefoxime treatment group (P 0.05), and compared with cefozoxime treatment group, levofloxacin lactate treatment group had vomiting and abdominal pain. The remission time of abdominal distension was shortened (P 0.01), the time of open diet was shortened, the days of hospitalization was shortened (P 0.05), the time of routine blood routine CRP and serum amylase returned to normal were prematurely (P 0.05), and the absorption of imaging pancreatitis was rapid (P 0.05). Conclusion in the treatment of acute edematous biliary pancreatitis, it is possible to prevent infection. The effect of levofloxacin lactate was better than that of cefazoxime.
【作者单位】：第二军医大学长海医院急诊科;
【分类号】：R576

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