甲状腺功能亢进症患者出现肝功能损害的相关分析

发布时间：2018-03-30 15:53

本文选题：甲亢　切入点：肝功能损害　出处：《广西医科大学》2014年硕士论文

【摘要】：目的：分析甲状腺功能亢进症患者出现肝功能损害的原因、临床表现、影响因素，为临床诊治甲亢出现肝功能损害提供指导。方法：总结我院内分泌代谢病科2012年3月至2014年2月收治的122例甲亢病例，根据肝功能检测结果分为肝功能正常组（A组51例）和肝功能损害组（B组71例），比较两组病例的一般情况、肝功能指标及甲状腺功能指标，，分析71例甲亢患者出现肝功能损害的临床资料，并对各因素进行相关分析。结果：B组71例甲亢患者出现肝功能损害中，甲亢所致有52例（占73.2％）、抗甲亢药物（ATD）所致有16例（占22.5％）、甲亢合并病毒性肝炎所致有2例（占2.8％）、甲亢合并自身免疫性肝病所致有1例（占1.4％）。A、B两组患者的性别、年龄、病程、FT3、FT4、TT3、TT4、TSH、ALT、AST、ALP进行比较分析，B组患者的FT4、TT3、TT4、TSH、ALT、AST、ALP高于A组，尤以FT4和TSH为显著，存在显著性差异（P0.01）。甲亢所致肝功能损害组肝功能指标的相关性分析，经SPSS计算，AST与FT3、FT4、TT3呈正相关，P0.05； ALT与FT3、FT4、TT3、TT4呈正相关，P0.05。各病因所致肝功能损害各有其临床特点，予积极治疗原发病及病因治疗后肝功能多能恢复正常。结论：甲亢患者出现肝功能损害病因各有不同，以甲亢所致肝功能损害者多见，肝功能损害和甲状腺激素水平升高有密切关系。
[Abstract]:Objective: to analyze the causes, clinical manifestations and influencing factors of liver function damage in hyperthyroidism patients, and to provide guidance for the diagnosis and treatment of hyperthyroidism. Methods: 122 cases of hyperthyroidism from March 2012 to February 2014 in our department of endocrine and metabolic diseases were summarized. According to the results of liver function test, the patients were divided into normal group (n = 51) and group B (n = 71). The general condition, liver function index and thyroid function index were compared between the two groups. The clinical data of 71 patients with hyperthyroidism were analyzed and the related factors were analyzed. Results in group B, 71 patients with hyperthyroidism had liver function damage. There were 52 cases of hyperthyroidism (73.2%), 16 cases of antihyperthyroidism (22.5%), 2 cases of hyperthyroidism complicated with viral hepatitis (2.8T), 1 case of hyperthyroidism complicated with autoimmune liver disease (1.4%). The course of the disease FT _ 3 / T _ 3H _ T _ 3T _ 4 / T _ 4 T _ 4 T _ (4) T _ (4) T _ (4) T _ (3) T _ (4) T _ (4) T _ (4) T _ (T) ALP in patients with hyperthyroidism was higher than that in group A, especially in FT4 and TSH, and there was significant difference between them (P0.01. the correlation analysis of liver function indexes in hyperthyroidism group) was also carried out in the patients with hyperthyroidism. There was a positive correlation between SPSS and FT _ 3T _ 4T _ 3 and ALT and FT _ 3T _ 4 / TT _ 3T _ 4.The liver function damage caused by each etiology had its own clinical characteristics, and the liver function returned to normal after active treatment and etiological treatment. Conclusion: the etiology of liver function damage in patients with hyperthyroidism is different. The liver function damage caused by hyperthyroidism is more common, and the liver function damage is closely related to the increase of thyroid hormone level.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R581.1;R575

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