自拟清肝和胃饮联合马来酸曲美布汀片辨治肝胃郁热证功能性消化不良的临床研究

发布时间：2018-03-31 08:10

本文选题：功能性消化不良　切入点：肝胃郁热证　出处：《辽宁中医杂志》2017年11期

【摘要】：目的:观察自拟清肝和胃饮联合马来酸曲美布汀片辨治肝胃郁热证功能性消化不良的临床效果。方法:选择就诊于本院的肝胃郁热证功能性消化不良患者204例为对象,随机分为对照组和观察组各102例。对照组患者给予马来酸曲美布汀片口服;观察组患者则加用自拟清肝和胃饮治之。比较两组治疗的临床疗效,评价中医证候积分及生活质量,监测用药前后血清一氧化氮(NO)、生长抑素(SS)、5-羟色胺(5-HT)及P物质(SP)水平。结果:观察组有效率92.1%高于对照组的78.4%(P0.05);治疗后观察组中医证候积分显著低于对照组(P0.05);经治疗后观察组患者情绪、躯体、角色、社会、认知等方面的生活质量评分显著高于对照组患者(P0.05);治疗后观察组患者NO、SS、5-HT水平与对照组比较显著降低,而SP水平则显著升高(P0.05)。结论:自拟清肝和胃饮联合马来酸曲美布汀片利于缓解肝胃郁热证功能性消化不良患者的临床症状,提高生活质量,疗效肯定,其机制与调控NO、SS、5-HT及SP水平以促进胃肠动力、加快胃肠蠕动有一定相关性。
[Abstract]:Objective: to observe the clinical effect of treating functional dyspepsia with Qinggan and Wei Yin combined with trimebutine maleate tablets. Methods: 204 patients with functional dyspepsia of liver and stomach stagnation heat syndrome were selected. The patients in the control group were given trimebutine maleate tablets orally, while the patients in the observation group were treated with self-made Qinggan and Weiyin. The clinical effects of the two groups were compared, and the TCM syndromes score and quality of life were evaluated. The levels of serum nitric oxide (no), somatostatin (SS) serotonin 5-HT (5-HT) and substance P substance (SP) were monitored before and after treatment. Results: the effective rate of observation group was 92.1% higher than that of control group (78.4%, P 0.05), the TCM syndrome score of observation group was significantly lower than that of control group (P 0.05), and that of observation group was significantly lower than that of control group (P 0.05). The mood of the patients in the post-observation group, The scores of quality of life in body, role, society and cognition were significantly higher than those in the control group (P 0.05), and the levels of NOSSS 5-HT in the observation group were significantly lower than those in the control group after treatment. Conclusion: the self-made Qinggan and Weiyin combined with trimebutine maleate tablets can relieve the clinical symptoms of patients with functional dyspepsia of liver-stomach stagnation heat syndrome, improve the quality of life, and have a positive curative effect. The mechanism is related to regulating the levels of 5-HT and SP in order to promote gastrointestinal motility and accelerate gastrointestinal peristalsis.
【作者单位】：海洋石油总医院;
【分类号】：R57

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