乳果糖联合枯草杆菌二联活菌治疗功能性便秘的临床观察

发布时间：2018-03-31 20:38

本文选题：功能性便秘　切入点：枯草杆菌二联活菌　出处：《中国药房》2015年32期

【摘要】：目的:观察乳果糖联合枯草杆菌二联活菌治疗功能性便秘的临床疗效与安全性。方法:采用随机单盲对照研究,将60例功能性便秘患者随机分为治疗组28例与对照组32例。两组患者均口服乳果糖,治疗组患者加服枯草杆菌二联活菌,对照组患者加服安慰剂,2周后均停用乳果糖,加服药物直至第4周再停用。比较两组患者治疗前与治疗后第2、4周的排便次数、粪便性状、便秘症状、生活质量及不良反应。结果:两组患者在第2周的排便次数、粪便性状、便秘症状均较治疗前明显改善,差异有统计学意义(P0.05);停服乳果糖后,治疗组患者在第4周的上述便秘各项指标改善情况明显优于对照组,差异有统计学意义(P0.05);两组患者的生活质量各指标在第4周均较治疗前改善,差异有统计学意义(P0.05),其中治疗组在躯体不适、满意度评分及总分方面较对照组改善明显,差异有统计学意义(P0.05);两组患者均未出现严重不良反应。结论:乳果糖联合枯草杆菌二联活菌能有效缓解功能性便秘,改善腹部症状,减缓便秘的复发,安全可靠。
[Abstract]:Objective: to observe the efficacy and safety of lactulose combined with Bacillus subtilis in the treatment of functional constipation.Methods: 60 patients with functional constipation were randomly divided into treatment group (n = 28) and control group (n = 32).The patients in the two groups were given lactulose, the patients in the treatment group were given Bacillus subtilis and the patients in the control group were treated with placebo for 2 weeks. The patients in the control group were stopped taking lactofructose until the 4th week.The defecation times, fecal traits, constipation symptoms, quality of life and adverse reactions were compared between the two groups before and after treatment.Results: the defecation times, fecal traits and constipation symptoms of the two groups were significantly improved in the second week compared with those before treatment (P 0.05).The improvement of each index of constipation in the treatment group was significantly better than that in the control group at the 4th week, and the difference was statistically significant (P 0.05), and the quality of life of the two groups was improved at the 4th week compared with that before treatment.The difference was statistically significant (P 0.05). The scores of somatic discomfort, satisfaction and total score in the treatment group were significantly improved than those in the control group (P 0.05), and no serious adverse reactions were found in the two groups.Conclusion: lactofructose combined with Bacillus subtilis can effectively relieve functional constipation, improve abdominal symptoms, ease the recurrence of constipation, and be safe and reliable.
【作者单位】：重庆医科大学附属第一医院消化内科;
【分类号】：R574.62

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