黄芩汤加减联合培菲康胶囊对溃疡性结肠炎的干预效果及对免疫功能的影响

发布时间：2018-04-02 19:51

本文选题：黄芩汤　切入点：培菲康胶囊　出处：《中华中医药学刊》2015年06期

【摘要】：目的:观察黄芩汤加减联合培菲康胶囊对溃疡性结肠炎的干预效果及对免疫功能的影响。方法:将所有于医院消化科就诊的溃疡性结肠炎患者共70例,随机分为治疗组与对照组两组,每组各35例。所有患者均接受一般常规治疗,此外,对照组采用口服美沙拉秦缓释颗粒联合培菲康胶囊的方法治疗。治疗组采用口服培菲康胶囊联合中药汤剂黄芩汤的方法治疗。两组疗程均为2个月,疗效结束后观察疗效。结果:在两组临床总有效率比较中,治疗组为85.7%,对照组为65.0%,两组相比,有统计学差异(P0.05)。在两组治疗前后临床症状评分比较中,治疗组与对照组治疗后的评分较治疗前均有所降低,但治疗组下降低比对照组明显,两组相比,有统计学差异(P0.05)。在两组治疗前后免疫球蛋白Ig A、Ig G、Ig M水平比较中,治疗组与对照组治疗后的Ig A、Ig G较治疗前均有所降低,但治疗组下降比对照组明显,两组相比,有统计学差异(P0.05)。在两组治疗前后细胞因子TNF-α、IL-10水平比较中,治疗组治疗后TNF-α水平明显下降,IL-10水平明显升高,与对照组治疗后相比,有统计学差异(P0.05)。结论:采用黄芩汤加减联合培菲康胶囊治疗溃疡性结肠炎可以明显提高临床有效率,有效地改善患者临床症状,且治疗过程中不良反应较少,未见明显不良反应,值得临床推广应用。
[Abstract]:Aim: to observe the effect of Huangqin decoction combined with Peifeikang capsule on ulcerative colitis and its immune function.Methods: a total of 70 patients with ulcerative colitis were randomly divided into treatment group and control group with 35 cases in each group.All patients received general routine treatment, in addition, the control group was treated by oral mezalazin sustained release granules combined with Peifeikang capsule.The treatment group was treated by oral Peifeikang capsule combined with traditional Chinese medicine decoction Huangqin decoction.The course of treatment in both groups was 2 months, and the curative effect was observed after the end of the curative effect.Results: in the two groups, the total effective rate was 85.7 in the treatment group and 65.0 in the control group. There was statistical difference between the two groups (P 0.05).In the comparison of clinical symptom scores before and after treatment, the scores of the treatment group and the control group were lower than those of the control group, but the decrease of the treatment group was more obvious than that of the control group, and there was significant difference between the two groups (P 0.05).Before and after treatment, the levels of immunoglobulin Ig G G G M in the treatment group and the control group were lower than those before and after treatment, but the decrease in the treatment group was more obvious than that in the control group, and there was significant difference between the two groups (P 0.05).Before and after treatment, the levels of TNF- 伪 and IL-10 in the treatment group were significantly decreased and the level of IL-10 was significantly increased, which was significantly different from that in the control group (P 0.05).Conclusion: the treatment of ulcerative colitis with Huangqin decoction and Peifeikang capsule can improve the clinical effective rate and improve the clinical symptoms effectively.It is worth popularizing and applying in clinic.
【作者单位】：台州市中心医院;
【分类号】：R574.62

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