剪切波组织定量技术联合代谢指标定量评估非酒精性单纯性脂肪肝的探索性研究

发布时间：2018-04-03 12:15

本文选题：剪切波组织定量技术　切入点：代谢指标　出处：《中国超声医学杂志》2015年07期

【摘要】：目的初步探索剪切波组织定量(Elast PQ)技术评价非酒精性单纯性脂肪肝(NAFL)的可行性,及与代谢指标的相关性,综合评估Elast PQ技术联合代谢指标对NAFL的临床诊断价值。方法应用基于Elastographic基础上的超声弹性成像新技术——Elast PQ,对58例正常体检者与46例NAFL患者行肝脏硬度检测,通过ROC曲线确定NAFL的诊断界值;并综合分析各检测指标与NAFL的相关性。结果肝脏Elast PQ值在正常人群与NAFL患者中存在显著统计学差异;通过统计计算ROC曲线下最大面积为0.88±0.02,面积的标准误为0.02,Elast PQ用于评估NAFL有明显统计学意义,95%置信区间(0.817、0.936)。Elast PQ值为3.61kPa时,对应的灵敏度及特异度最高,分别为89%、69%。WHR、BMI、TG、CHO、LDL-C在正常组与病例组中比较,差异具有统计学意义(P0.05);肝脏Elast PQ值在NAFL组和正常组中分别与AST/ALT、WHR存在正相关。结论 Elast PQ技术联合代谢指标对NAFL的定量评估是可行的,具有良好的临床应用前景。
[Abstract]:Objective to explore the feasibility of using shear wave tissue quantitative analysis (Elast PQ) technique to evaluate the clinical diagnostic value of Elast PQ combined with metabolic indexes in patients with nonalcoholic fatty liver disease (NAFLL).Methods Elast PQ, a new ultrasonic elastic imaging technique based on Elastographic, was used to detect the liver hardness of 58 normal controls and 46 NAFL patients. The diagnostic threshold of NAFL was determined by ROC curve, and the correlation between the detection indexes and NAFL was analyzed synthetically.Results there was significant statistical difference in Elast PQ between normal subjects and NAFL patients, and the maximum area under ROC curve was 0.88 卤0.02, and the standard error of area was 0.02% Elast PQ was used to evaluate the value of NAFL with a statistical significance of 0.817% confidence interval (0.817%), 0.936% 路Elast PQ value was 3.61kPa.The corresponding sensitivity and specificity were the highest, 89%. The difference of LDL-C between normal group and case group was statistically significant (P 0.05), and there was a positive correlation between liver Elast PQ and AST / alt WHR in NAFL group and normal group, respectively.Conclusion the quantitative evaluation of NAFL by Elast PQ combined with metabolic index is feasible and has a good clinical application prospect.
【作者单位】：兰州大学第一医院超声科;
【分类号】：R575.5;R445.1

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