幽门螺杆菌感染和Barrett食管的相关性Meta分析

发布时间：2018-04-05 08:44

  本文选题：幽门螺杆菌　切入点：Barrett食管　出处：《重庆医学》2015年27期

【摘要】：目的探讨幽门螺杆菌(Hp)感染与Barrett食管发生发展的关系。方法采用计算机检索和手工检索相结合的方法搜索Pubmed、CNKI、OVID、Wiley InterScience、万方数据库、Embase数据库,时间从建库到2014年1月,纳入分析Hp感染与Barrett食管相关性的病例对照研究。使用RevMan 5.2及Stata 12.0进行Meta分析,采用I2检验判断各研究间的异质性,敏感性分析评估其结果稳定性,应用Begg′s漏斗图和Egger′s回归图评价发表偏倚。结果共纳入14篇文献,病例组2 103例,对照组内镜检查健康者7 009例,胃食管反流性疾病(GERD)患者2 213例。Barrett食管患者的Hp感染率及CagA阳性的Hp感染率,与健康者比较(OR=0.60,95%CI:0.52~0.68;OR=0.24,95%CI:0.11~0.52);Barrett食管患者的Hp感染率及CagA阳性的Hp感染率,与GERD患者比较(OR=0.02,95%CI:0.06~0.02;OR=0.44,95%CI:0.14~1.45)。结论 Hp尤其是CagA阳性的菌株可能对Barrett食管的发生有保护作用。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (HP) infection and the development of Barrett esophagus.Methods the method of computer search and manual search was used to search the Embase database of Pubmedus CNKIIDOVIDE Wiley InterScience. from the time of establishment to January of 2014, a case-control study was carried out to analyze the correlation between HP infection and Barrett esophagus.RevMan 5.2 and Stata 12.0 were used for Meta analysis, I 2 test was used to judge the heterogeneity of each study, sensitivity analysis was used to evaluate the stability of the results, and Begg's funnel diagram and Egger's regression diagram were used to evaluate publication bias.Results there were 2 103 cases in the case group, 7 009 cases in the control group and 2 213 cases in the patients with gastroesophageal reflux disease (GERD). The HP infection rate and CagA positive HP infection rate in the patients with Barrett's esophagus were studied.涓庡仴搴疯，

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