2型糖尿病合并非酒精性脂肪性肝病患者发生房颤的危险因素

发布时间：2018-04-05 23:27

本文选题：型糖尿病　切入点：非酒精性脂肪性肝病　出处：《重庆医科大学学报》2017年07期

【摘要】：目的:探讨2型糖尿病合并非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者发生心房纤颤(atrial fibrillation,AF)的危险因素。方法:选取2010年9月至2014年6月我院2型糖尿病合并NAFLD患者共208例,收集一般临床资料,常规检查心电图,腹部彩超,将入组患者分为房颤组和非房颤组,然后采用多因素logistic回归模型筛选主要危险因素。结果:房颤组患者的体质量指数、糖化血红蛋白、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇、甘油三酯、谷草转氨酶、谷氨酰转肽酶水平明显高于非房颤组(P0.05);同时,房颤组患者中有糖尿病家族史、脂肪肝家族史、吸烟比例亦明显高于非房颤组(P0.01),且年龄明显高于非房颤组患者(P0.01)。单因素logistic回归分析表明:2型糖尿病合并NAFLD患者发生房颤与性别、年龄、体质指数、糖尿病家族史、脂肪肝家族史、高血压、糖化血红蛋白、总胆固醇、低密度脂蛋白显著相关(P0.05);多因素logistic回归分析表明:仅年龄和TC是2型糖尿病合并NAFLD患者发生房颤的危险因素(OR=2.769,95%CI=1.329~5.769,P=0.007;OR=1.435,95%CI=1.027~2.014,P=0.005)。结论:年龄和TC是2型糖尿病合并NAFLD患者发生房颤的危险因素,对于2型糖尿病合并NAFLD的患者更应注意对胆固醇的控制。
[Abstract]:Objective: to investigate the risk factors of atrial fibrillation (AF) in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease.Methods: from September 2010 to June 2014, 208 patients with type 2 diabetes mellitus complicated with NAFLD in our hospital were selected. The general clinical data, electrocardiogram (ECG) and abdominal color Doppler ultrasonography were collected. The patients were divided into atrial fibrillation group and non-atrial fibrillation group.Then the multivariate logistic regression model was used to screen the main risk factors.Results: the body mass index, glycosylated hemoglobin, total cholesterol total cholesterol (TC), low density lipoprotein cholesterol, triglyceride, aspartate aminotransferase and glutamyl transpeptidase levels in AF group were significantly higher than those in non-AF group (P 0.05).The family history of diabetes mellitus and fatty liver in AF group was higher than that in non-AF group (P 0.01), and the age was significantly higher than that in non-AF group (P 0.01).Univariate logistic regression analysis showed that atrial fibrillation and gender, age, body mass index, family history of diabetes, family history of fatty liver, hypertension, glycosylated hemoglobin, total cholesterol were found in patients with type 2 diabetes mellitus complicated with NAFLD.Conclusion: age and TC are risk factors for atrial fibrillation in patients with type 2 diabetes mellitus and NAFLD, and cholesterol control should be paid more attention to in patients with type 2 diabetes mellitus with NAFLD.
【作者单位】：重庆市第三人民医院消化内科;
【分类号】：R541.75;R575.5;R587.1

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