腹腔注射白细胞介素-2治疗肝硬化腹腔积液并自发性腹膜炎的效果观察

发布时间：2018-04-06 00:06

本文选题：白细胞介素-　切入点：腹腔注射　出处：《广东医学》2017年13期

【摘要】：目的观察腹腔注射白细胞介素-2(IL-2)治疗肝硬化腹腔积液合并自发性腹膜炎的疗效。方法将83例患者分为观察组45例,对照组38例,两组均常规处理,观察组加用160万U的IL-2腹腔注射,隔天1次,疗程2周。结果观察组治疗后腹胀、腹痛现象明显减少,与对照组治疗后比较差异有统计学意义(P0.05)。两组治疗后肝功能、血常规均明显改善(P0.05),其中观察组治疗后总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)低于对照组(P0.05)。两组治疗后,白细胞计数(WBC)、中性粒细胞(PMN)和降钙素原(PCT)均明显改善(P0.05),且治疗后上述指标改善情况观察组优于对照组(P0.05)。观察组治疗后细菌培养阳性比例明显降低(P0.05),且同时低于对照组(P0.05)。治疗及随访1个月内两组均未出现明显不良反应。结论腹腔注射IL-2可提高治疗肝硬化腹腔积液合并自发性腹膜炎患者治疗效果,对控制腹水感染效果尤佳。
[Abstract]:Objective to observe the efficacy of intraperitoneal injection of interleukin-2 (IL-2) in the treatment of cirrhotic celiac effusion with spontaneous peritonitis.Methods Eighty-three patients were divided into the observation group (n = 45) and the control group (n = 38). The two groups were treated with routine treatment. The observation group was treated with 1.6 million U IL-2 intraperitoneal injection once every other day for 2 weeks.Results after treatment, abdominal distension and abdominal pain in the observation group were obviously reduced, and the difference was statistically significant compared with that in the control group (P 0.05).The liver function and blood routine of the two groups were significantly improved after treatment. The total bilirubin and alanine aminotransferase (alt) in the observation group were lower than those in the control group (P 0.05).After treatment, WBC count, neutrophil PMN (PMN) and procalcitonin (PCT) were significantly improved in both groups, and the improvement of the above indexes in the observation group was better than that in the control group (P 0.05).The positive rate of bacteria culture in the observation group was significantly lower than that in the control group after treatment.There were no significant adverse reactions in both groups during 1 month of treatment and follow-up.Conclusion Intraperitoneal injection of IL-2 can improve the therapeutic effect in patients with cirrhotic peritoneal effusion and spontaneous peritonitis, especially in the control of ascites infection.
【作者单位】：广州医科大学附属第五医院消化内科;
【分类号】：R572.2;R575.2

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