中国北方地区肝硬化病因及合并症的变迁

发布时间：2018-04-07 18:49

本文选题：肝硬化　切入点：病因　出处：《首都医科大学学报》2017年04期

【摘要】：目的阐明中国北方地区肝硬化病因及其合并症的变迁。方法回顾性分析2002年1月1日至2013年12月31日间首次住院的肝硬化病人人口学信息及其合并症,以2年为一时间段,分析中国北方地区肝硬化病因构成及合并症的变迁。结果12年间共12 948例肝硬化病人,其中男性8 937例(69.02%),女性4 011例(30.98%)。平均年龄(51.29±11.81)岁(7~93岁)。乙型肝炎病毒(hepatitis B virus,HBV)/丙型肝炎病毒(hepatitis C virus,HCV)相关及酒精性肝硬化以男性为主,而自身免疫性肝病所致肝硬化、药物性及非酒精脂肪性肝硬化以女性为主。住院肝硬化病人逐年增加,其病因构成变化:HBV相关肝硬化从86.72%降至78.65%(P0.01),HCV相关肝硬化从8.07%升至19.27%(P0.01)。酒精性、自身免疫性肝病所致肝硬化及不明原因肝硬化分别从7.68%至16.52%、2.65%至10.0%、0.72%至5.27%(P0.01),非酒精性脂肪性肝硬化占3.76%(P0.01)。腹水为最常见的合并症,占66.34%,单纯腹水、消化道出血构成比呈减少趋势,而2个以上合并症者呈增加趋势。结论住院肝硬化病人逐年增加,HCV相关性、酒精性、自身免疫性肝病所致肝硬化及非酒精性脂肪性肝硬化显著增加,HBV相关肝硬化减少。腹水、消化道出血仍为主要合并症,其构成比呈逐年减少趋势。
[Abstract]:Objective to elucidate the etiology and complications of cirrhosis in northern China.Methods the demographic information and complications of the first inpatients with cirrhosis from January 1, 2002 to December 31, 2013 were analyzed retrospectively. The etiological factors and complications of cirrhosis in northern China were analyzed in a period of 2 years.Results there were 12 948 patients with liver cirrhosis in 12 years, of whom 8 937 cases were male and 4 011 cases were female.The mean age was 51.29 卤11.81) years old.Hepatitis B virus hepatitis B virus / hepatitis C virus hepatitis C virus (HCV) related and alcoholic cirrhosis were mainly found in males, while those caused by autoimmune liver diseases, drug-induced and non-alcoholic fatty cirrhosis were mainly female.The number of inpatients with liver cirrhosis increased year by year, the etiological composition of which decreased from 86.72% to 78.65%. The percentage of HCV-associated cirrhosis increased from 8.07% to 19.27%.Alcoholic, autoimmune liver cirrhosis and unexplained cirrhosis ranged from 7.68% to 16.52% from 2.65% to 10.0% to 0.72% to 5.27%, respectively. Non-alcoholic fatty liver cirrhosis accounted for 3.76% of P 0.01.Ascites was the most common complication, accounting for 66.34. The composition ratio of ascites and gastrointestinal bleeding decreased, while more than two complications showed an increasing trend.Conclusion the incidence of HCV, alcohol, autoimmune liver cirrhosis and non-alcoholic fatty cirrhosis increased significantly in inpatients with liver cirrhosis.Ascites, gastrointestinal bleeding is still the main complication, its composition ratio decreases year by year.
【作者单位】：首都医科大学附属北京佑安医院肝病消化中心;
【基金】：北京市医院管理局临床医学发展专项(ZYLX201610) 登峰计划专项(DFL20151602) 首都发展基金专项(2014-1-2181) 佑安肝病艾滋病基金(20150103)~~
【分类号】：R575.2

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