基于MRCP图像的胆管形态学特征分析与研究

发布时间：2018-04-08 08:22

本文选题：磁共振胰胆管成像　切入点：胆管　出处：《北京交通大学》2017年硕士论文

【摘要】：胆管结石在我国是一种常见的胆道系统疾病,现阶段缺乏定量计算胆管形态学特征的方法,限制了特征分析在胆管结石影像学检查结果中的应用。本文提出了一种以 MRCP(Magnetic Resonance Cholangiopancreatography,磁共振胰胆管成像)图像为研究对象的胆管结石三维图像处理与形态特征定量分析方法,并初步分析了胆管形态学特征与影像学诊断结果之间的关系。本文主要完成以下两方面工作:(1)针对手工难以实现胆管三维形态特征定量分析的问题,给出了一种胆管三维形态学特征参数的计算机分析方法。选取MRCP三维Dicom图像序列,利用图像分割、三维骨架化处理获取胆管三维中心线,在此基础上通过计算获取胆管长度、半径和三维曲率等形态学特征信息。通过临床26例MRCP图像病例验证,证实了该方法应用于胆管形态学特征信息提取的可行性和有效性。(2)针对胆管三维形态学特征参数与患者临床信息相关性分析不足的现状,探讨了胆管形态学特征与临床信息的关联性。利用箱型图和独立样本t检验,统计分析胆管形态学特征参数与患者基本信息、临床诊断情况之间的关系。在已有的临床数据集上进行关联性的分析,结果表明:性别对胆管长度和曲率平均值有影响,年龄对胆管半径最大值有影响,胆管长度和半径最大值对结石的CT诊断结果有影响。本文利用三维图像处理方法实现了胆管的形态学特征参数的定量提取,获得了胆管形态学特征与胆管结石患者临床数据、影像学诊断漏诊情况的相关性,为进一步开展胆结石的计算机辅助诊断研究提供了可参考的图像处理方法和理论分析基础。
[Abstract]:Choledocholithiasis is a common disease of bile duct system in China. At present, there is a lack of quantitative method to calculate the morphological characteristics of bile duct, which limits the application of feature analysis in imaging examination of bile duct stones.In this paper, a method of 3D image processing and quantitative analysis of morphologic features of cholangiopancreatography (MRCP(Magnetic Resonance cholangiopancreatography) is presented.The relationship between the morphological features of bile duct and imaging diagnosis was analyzed.In order to solve the problem that it is difficult to realize the quantitative analysis of the three-dimensional morphological characteristics of bile duct by hand, this paper presents a computer analysis method for the three-dimensional morphological characteristics of bile duct.The MRCP 3D Dicom image sequence was selected, and the three-dimensional central line of the bile duct was obtained by image segmentation and three-dimensional skeleton processing. On this basis, morphological information such as the length, radius and three-dimensional curvature of the bile duct were obtained.The feasibility and effectiveness of this method in extracting bile duct morphological feature information were confirmed by clinical MRCP images in 26 cases. (2) aiming at the lack of correlation analysis between three-dimensional morphological parameters of bile duct and clinical information of patients, the present situation of this method is proved.The relationship between the morphological features of bile duct and clinical information was discussed.The relationship between the characteristic parameters of bile duct morphology and the basic information of patients and clinical diagnosis was analyzed by using box diagram and independent sample t-test.The results of correlation analysis on existing clinical data sets showed that gender had an effect on the mean length and curvature of bile duct, age on the maximum radius of bile duct.The maximum length and radius of bile duct have influence on CT diagnosis of stone.In this paper, the quantitative extraction of the morphological parameters of bile duct was realized by using three-dimensional image processing method. The correlation between the morphological features of bile duct and clinical data of patients with cholelithiasis and the missed diagnosis of imaging diagnosis was obtained.It provides a reference image processing method and theoretical analysis basis for the further study of computer aided diagnosis of gallstones.
【学位授予单位】：北京交通大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R575.62;TP391.41

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