新疆维吾尔族自身免疫性肝病患者自身抗体谱的研究分析

发布时间：2018-04-08 15:54

本文选题：自身免疫性肝炎　切入点：原发性胆汁性肝硬化　出处：《重庆医学》2016年19期

【摘要】：目的分析新疆维吾尔族不同类型自身免疫性肝病患者的自身抗体阳性率及其诊断意义。方法选取2012年10月至2014年10月该院门诊和住院的维吾尔族自身免疫性肝病患者51例,其中自身免疫性肝炎(AIH)20例(AIH组),原发性胆汁性肝硬化(PBC)31例(PBC组),采用间接免疫荧光法、免疫印迹法检测其血清生化指标和自身抗体,并进行比较分析。结果两组各项生化指标水平均明显增高,其中两组丙氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(γ-GT)、碱性磷酸酶(ALP)及免疫球蛋白M(IgM)水平比较,差异均有统计学意义(P0.05)。AIH组患者抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗肝肾微粒体-1(LKM-1)抗体、抗肝细胞溶质抗原1型(LC-1)抗体、抗可溶性肝抗原/肝胰抗原(SLA/LP)抗体及抗线粒体抗体(AMA)阳性率分别为65.0%、40.0%、10.0%、5.0%、10.0%、5.0%;PBC组患者ANA、AMA及其M2亚型(AMA-M2)的阳性率分别为61.3%、100.0%和96.8%。结论新疆地区维吾尔族自身免疫性肝病患者的自身抗体谱具有一定的特征,自身抗体谱的检测对自身免疫性肝病诊断、分型及鉴别诊断具有重要的意义。
[Abstract]:Objective to analyze the positive rate of autoantibodies in Xinjiang Uygur different types of autoimmune liver disease patients and its clinical significance. Methods 51 cases of patients from October 2012 to October 2014 in the hospital outpatient and inpatient Uygur autoimmune liver diseases, including autoimmune hepatitis (AIH) in 20 cases (group AIH), primary biliary cirrhosis (PBC) in 31 cases (group PBC), using indirect immunofluorescence method, serum biochemical indexes and autoantibody immunoblotting, and comparative analysis. The results of two groups of biochemical indexes were significantly higher among two groups, alanine aminotransferase (ALT), gamma glutamyltransferase (gamma -GT), alkaline phosphatase (ALP) and immunoglobulin M (IgM) level, the differences were statistically significant (P0.05) antibody in.AIH group (ANA), anti smooth muscle antibody (SMA), -1 (LKM-1) anti liver kidney microsomal antibody, anti liver cytosolic antigen 1 Type (LC-1) antibody, anti soluble liver antigen / liver pancreas (SLA/LP) antibody and anti mitochondrial antibody (AMA) positive rates were 65%, 40%, 10%, 5%, 10%, 5%; PBC group ANA, AMA and M2 subtype (AMA-M2) positive rate was 61.3%, 100% patients of Uygur conclusion the 96.8%. and Xinjiang area of autoimmune liver disease autoantibodies have certain characteristics of autoantibodies detection for diagnosis of autoimmune liver disease, has the important significance of typing and differential diagnosis.

【作者单位】：新疆医科大学第一附属医院医学检验中心;
【基金】：新疆维吾尔自治区自然科学基金项目(2014211C047)
【分类号】：R575

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