不同剂量生长抑素治疗肝硬化合并食管胃底静脉曲张破裂出血的临床效果研究

发布时间：2018-04-10 01:32

  本文选题：肝硬化　切入点：食管和胃静脉曲张　出处：《中国全科医学》2017年19期

【摘要】：目的探讨不同剂量生长抑素治疗肝硬化合并食管胃底静脉曲张破裂出血的临床效果。方法选取2013—2015年入住海南省人民医院急诊ICU及消化内科的符合纳入标准的102例肝硬化合并食管胃底静脉曲张破裂出血患者,根据随机数字表法将患者分为标准剂量组(A组)和加倍剂量组(B组),各51例。依据患者就诊时既往出血次数(是否2次)对A、B两组依次再分为A1组(既往出血2次)、A2组(既往出血≥2次),B1组(既往出血2次)、B2组(既往出血≥2次)。A组给予生长抑素首剂4.1 ml静脉注射后,再给予生长抑素4.1 ml/h持续泵入,持续5 d。B组给予生长抑素首剂8.2 ml静脉注射后,再给予生长抑素8.2 ml/h持续泵入,持续5 d。比较A组和B组、A1组和B1组、A2组和B2组的首次止血成功率、再出血率、治疗有效率、病死率。结果 B组的首次止血成功率、治疗有效率高于A组,再出血率低于A组(P0.05)。B2组的首次止血成功率高于A2组,再出血率低于A2组(P0.05)。结论对于肝硬化合并食管胃底静脉曲张破裂出血患者,加倍剂量生长抑素治疗是有效的,尤其是对于既往出血≥2次的患者,可以明显降低再出血率。
[Abstract]:Objective to investigate the clinical effect of different doses of somatostatin in the treatment of cirrhosis with esophageal varices bleeding.Methods 102 patients with cirrhosis complicated with esophageal and gastric variceal bleeding who were admitted to Hainan Provincial people's Hospital from 2013 to 2015 in emergency department of ICU and Department of Digestive Medicine were selected.Patients were randomly divided into two groups: standard dose group (n = 51) and double dose group (n = 51).According to the number of previous bleeding (2 times or not), the two groups were subdivided into group A1 (2 times of previous hemorrhage) and group A 2 (group B 1 with previous hemorrhage 鈮，

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