老年消化系统损伤与抗凝或抗血小板药物的相关性

发布时间：2018-04-10 19:18

  本文选题：消化系统损伤 + 抗凝或抗血小板药物　； 参考：《中国老年学杂志》2015年15期

【摘要】：目的评估抗凝及抗血小板药物造成消化系统损伤的临床特点和相关因素。方法收集该院收治的接受抗凝和(或)抗血小板药物(华法林、阿司匹林、氯吡格雷等)治疗的老年住院患者200例,未接受治疗老年患者100例,根据患者服用抗凝/抗血小板药物状况分为对照组和服药组,对各组患者的一般人口资料、消化道出血程度、出血方式、内镜检查特征等相关因素与患者服药类型及(INR)值进行统计学分析。结果服药组患者出现消化道出血发生率较对照组高(P=0.003),且呕血、便血及潜血阳性的发生率较对照组患者高(P=0.024,0.012,0.011),服药组INR≥3患者的比例和出血风险较对照组显著增高(P=0.008),服药组患者在胃窦、胃体及多发性溃疡发生率较对照组高(P=0.035,0.013和0.013),且溃疡面积(大溃疡、小溃疡)较对照组多(P=0.042,0.034),幽门螺杆菌感染率较对照组显著增高(P=0.01)。结论老年患者服用抗凝和/或抗血小板药物可能成为患者出现严重消化道出血、溃疡及不同程度感染的危险因素。
[Abstract]:Objective to evaluate the clinical characteristics and related factors of digestive system injury caused by anticoagulant and antiplatelet drugs.Methods 200 elderly inpatients treated with warfarin, aspirin, clopidogrel, and 100 elderly patients who were not treated with anticoagulant and / or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.) were collected.According to the status of anticoagulant / antiplatelet drugs, the patients were divided into two groups: control group and medication group.The characteristics of endoscopic examination and other related factors were statistically analyzed with the type of medication and the value of INR.Results the incidence of gastrointestinal hemorrhage in the drug group was higher than that in the control group.The positive rate of stool blood and occult blood was higher than that of the control group. The proportion and bleeding risk of patients with INR 鈮，

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