重症急性胰腺炎患者真菌感染特征分析

发布时间：2018-04-10 21:26

本文选题：重症急性胰腺炎 + 真菌感染　；参考：《中华医院感染学杂志》2016年16期

【摘要】：目的探讨重症急性胰腺炎(SAP)患者并发真菌感染的菌群分布特点及耐药性,为临床合理用药提供科学依据。方法选择2012年3月-2015年1月医院确诊的SAP患者364例,采集患者感染分泌物进行真菌培养及药敏试验,观察感染部位及菌落分布特征,并分析其耐药性,数据采用WHONET 5.0软件进行统计分析。结果 364例SAP患者中有63例发生真菌感染,感染率17.31%;感染部位分布在全身各处,共96例次,以肺部感染为主,共34例次占35.42%;在并发真菌感染的63例SAP患者中,分离培养出真菌96株,以白色念珠菌为主,共52株占54.17%;热带念珠菌、克柔念珠菌、光滑念珠菌、近平滑念珠菌对伏立康唑敏感率高,均为100.00%。结论 SAP患者并发真菌感染主要是以白色念珠菌为主,肺部易感染,临床可采用伏立康唑进行抗感染治疗。
[Abstract]:Objective to investigate the severe acute pancreatitis (SAP) patients with fungal infection of bacteria distribution and drug resistance, and provide scientific basis for clinical rational drug use. Methods 364 patients with SAP in March 2012 -2015 year in January the hospital diagnosed cases, collecting patients infected secretions were fungal culture and drug sensitivity test, the location and distribution of colony observation and analysis of infection. The resistance of WHONET 5 software was used for statistical analysis. Results 364 cases of patients with SAP in 63 cases of fungal infection, the infection rate was 17.31%; the distribution of infection in the body, a total of 96 cases with pulmonary infection, 34 cases, accounting for 35.42%; in 63 cases of SAP patients with fungal infection. Isolated 96 strains of fungi, Candida albicans, 52 strains accounted for 54.17%; Candida tropicalis, Candida krusei and Candida glabrata, Candida parapsilosis infection rate is high sensitive to voriconazole were 100.00%.. Conclusion SAP patients with fungal infection is mainly Candida albicans, lung infection, using voriconazole for clinical anti infection treatment.

【作者单位】：中日友好医院消化内科;中日友好医院重症医学科;中日友好医院急诊科;
【基金】：国家科技部“十二五”支撑计划基金资助项目(2014BAI08B02)
【分类号】：R576

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