尼古丁对溃疡性结肠炎疗效的meta分析

发布时间：2018-04-10 23:04

本文选题：溃疡性结肠炎 + 尼古丁　；参考：《福建医科大学》2014年硕士论文

【摘要】：目的：系统评价和Meta分析尼古丁治疗溃疡性结肠炎(UC)的有效性和安全性。方法：制定检索策略、原始文献纳入标准及排除标准，检索外文数据库PubMed(Medline)、Embase、OVID、the Cochrane Library；中文数据库万方、维普、相关期刊论文(CNKI)、谷歌学术搜索等，收集有关尼古丁治疗UC的研究资料，使用改良Jadad评分量表评价纳入分析的各项文献的质量，筛选出完全随机对照研究文献，利用统计软件RevMan5.2分析尼古丁对UC诱导缓解的疗效和安全性，计算OR值及其95％可信限范围(CI)。结果：检索到相关文献99篇，，其中6篇病例-对照研究文献纳入本meta分析。结果显示：与标准的治疗药物(糖皮质激素及美沙拉秦)相比，尼古丁透皮贴剂及灌肠剂对轻-中度UC患者的疗效并无优势(OR=0.90，95%CI：0.12-6.94)，且尼古丁组的不良反应更常见(OR=3.04，95%CI：1.94-4.78)，因为不良反应而退出研究的患者也更多(OR=4.40，95%CI：1.35-14.40)。但是，纳入2项研究共136例UC患者的meta分析研究显示：尼古丁透皮贴剂的疗效优于安慰剂(OR=3.19，95%CI：1.24-8.22)。结论：尼古丁透皮贴剂对UC诱导缓解的作用优于安慰剂，但不优于传统的治疗药物(糖皮质激素及美沙拉秦)，且尼古丁组的不良反应更常见，限制了它的临床应用。
[Abstract]:Objective: to evaluate the efficacy and safety of nicotine in the treatment of ulcerative colitis by Meta.Methods: the retrieval strategy was formulated, the criteria for the inclusion of original documents and the exclusion criteria were established, and the foreign language database PubMedline Medline was searched for the Cochrane Library, the Chinese databases Wan Fang, Weip, CNKI, Google academic search, etc.To collect the data of nicotine therapy for UC, to evaluate the quality of the literature included in the analysis by using the modified Jadad score scale, and to screen out the complete randomized controlled study literature.The statistical software RevMan5.2 was used to analyze the efficacy and safety of nicotine in UC induced remission. The OR value and its 95% confidence limit were calculated.Results: 99 articles were retrieved, 6 of which were included in the meta analysis.The results showed that compared with standard therapeutic drugs (glucocorticoid and meladin),However, meta analysis of 136 UC patients included in two studies showed that the efficacy of nicotine transdermal patch was better than that of placebo OR3. 19 / 95 CI: 1.24-8.22.Conclusion: the effect of nicotine transdermal patch on UC induced relief is better than that of placebo, but not superior to traditional treatment drugs (glucocorticoid and mesalazone), and the adverse effects of nicotine group are more common, which limits its clinical application.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574.62

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