缺氧诱导因子在肠缺氧中的研究进展

发布时间：2018-04-11 13:30

本文选题：缺氧诱导因子 + 腺苷　；参考：《肠外与肠内营养》2015年05期

【摘要】：肠系膜缺血性疾病和危重症病人的肠道血流减少、炎性激活会引起严重的肠缺血、缺氧状态。缺氧诱导因子(HIF)调控下游一系列基因转录,介导机体内源性炎性缓解机制的运行,参与肠道的适应性改变。在缺氧状态下,HIF蛋白转录后分解减少,使其能稳定存在并激活一系列下游基因参与,以缓解缺血后的肠损伤。目前受关注的有细胞内腺苷相关信号通路,尤其是A2B腺苷受体通路及缺氧诱导的神经生长因子-1介导缺血后信号通路。HIF介导的抗炎效应也参与缺血后肠功能的保护。血栓导致的肠缺血HIF还参与肠道血管的再通过程。HIF相关通路的研究为治疗肠缺氧损伤和继发多器官功能障碍提供诸多潜在靶点,针对相关靶点干预措施的研究也取得十分良好的效果,但目前还局限于细胞和转基因动物模型中。将来部分这类新型药物有可能从实验室转入临床,给肠道缺氧性疾病的治疗带来新的思路。以下将对HIF在肠缺氧中的最新研究作一综述。
[Abstract]:Intestinal blood flow in patients with mesenteric ischemic disease and severe illness is reduced, and inflammatory activation can lead to severe intestinal ischemia and anoxia.Hypoxia-inducible factor (HIFs) regulates downstream transcription of a series of genes, mediates the mechanism of endogenous inflammatory remission, and participates in the adaptive changes of intestinal tract.The reduction of post-transcriptional decomposition of HIF protein in anoxic state enables it to exist stably and activate a series of downstream genes to alleviate intestinal injury after ischemia.At present, the intracellular adenosine-related signaling pathways, especially the A2B adenosine receptor pathway and the hypoxia-induced nerve growth factor-1 signaling pathway. HIF-mediated anti-inflammatory effects also participate in the protection of intestinal function after ischemia.Thrombo-induced intestinal ischemia HIF is also involved in the process of intestinal vascular recanalization. HIF-related pathways provide a number of potential targets for the treatment of intestinal hypoxia injury and secondary multiple organ dysfunction.The research on relevant target intervention has also achieved good results, but it is still confined to cell and transgenic animal models.In the future, some of these new drugs may be transferred from laboratory to clinic, bringing new ideas to the treatment of intestinal hypoxic diseases.The following is a review of the latest studies of HIF in intestinal anoxia.
【作者单位】：南京军区南京总医院解放军普通外科研究所;
【分类号】：R574

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