难治性肠易激综合征—腹泻型相关危险因素

发布时间：2018-04-13 10:12

本文选题：肠易激综合征 + 难治性肠易激综合征　；参考：《重庆医科大学》2014年硕士论文

【摘要】：目的:探讨难治性肠易激综合征-腹泻型(IBS-D)的相关危险因素，为早期防治难治性IBS-D提供理论依据。方法:将门诊IBS-D患者共121例分为两组,其中难治性IBS-D组共56例和非难治性IBS-D组共65例，对比分析两组患者的性别、年龄、体质量指数、家族史、吸烟史、饮酒史、症状严重程度以及焦虑抑郁状况,通过单因素logistic回归分析筛选出与难治性IBS-D的相关危险因素，将这些有意义的相关危险因素纳入ROC曲线分析，以明确能够预测难治性IBS-D的危险因素的临界值。结果:难治性IBS-D组和非难治性IBS-D组在性别、年龄、体质量指数、家族史、吸烟史及饮酒史上比较无统计学意义。单因素logistic回归分析显示症状积分（OR=1.010，95%CI:1.005，1.015）、焦虑积分（OR=2.810，，95%CI:1.888，4.180）及抑郁积分（OR=1.637，95%CI:1.338，2.004）为难治性IBS-D的危险因素，ROC曲线分析显示临床症状积分、焦虑积分、抑郁积分的ROC曲线下面积（AUC）分别为0.757、0.919、0.796，其预测难治性IBS-D的临界点分别为183分、9分、6分。故临床症状积分183分、焦虑积分9分、抑郁积分6分对于预测难治性IBS-D具有重要意义。结论:症状积分、焦虑积分、抑郁积分为难治性IBS-D的危险因素,可作为预测的重要参考指标。
[Abstract]:Objective: to investigate the risk factors of refractory irritable bowel syndrome (IBS-D) and to provide theoretical basis for early prevention and treatment of refractory IBS-D.Methods: a total of 121 outpatients with IBS-D were divided into two groups: 56 patients in refractory IBS-D group and 65 patients in non-refractory IBS-D group. Sex, age, body mass index, family history, smoking history and drinking history were compared between the two groups.The severity of symptoms and anxiety and depression were analyzed by univariate logistic regression analysis. The risk factors associated with refractory IBS-D were screened out, and these significant risk factors were included in the ROC curve analysis.In order to be able to predict the critical value of refractory IBS-D risk factors.Results: there was no significant difference in sex, age, body mass index, family history, smoking history and drinking history between refractory IBS-D group and non-refractory IBS-D group.Univariate logistic regression analysis showed that the symptom score was 1.0105CI: 1.005, anxiety score was 2.8105CI: 1.8884.180) and depression score OR1.637C95CI: 1.3382.004) as a risk factor for refractory IBS-D, ROC curve analysis showed that the clinical symptom score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score and anxiety score.The area under the ROC curve of depression score was 0.757-0.919 ~ 0.796, and the critical point of predicting refractory IBS-D was 183, 9 and 6, respectively.Therefore, the clinical symptom score of 183, anxiety score of 9 and depression score of 6 are of great significance for the prediction of refractory IBS-D.Conclusion: symptom score, anxiety score and depression score are risk factors of refractory IBS-D.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574.4

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