慢性乙型肝炎白介素18及其结合蛋白与乙型肝炎病毒DNA载量的相关性

发布时间：2018-04-13 11:17

  本文选题：慢性乙型肝炎 + 白细胞介素-　； 参考：《中国老年学杂志》2015年14期

【摘要】：目的研究慢性乙型肝炎白介素(IL)-18及其结合蛋白与乙型肝炎病毒(HBV)DNA载量的相关性。方法将慢性乙型肝炎患者160例根据HBV-DNA载量不同分为高载量组和低载量组,检测两组患者的IL-18及其结合蛋白含量、肝纤维化指标以及免疫功能指标。结果 1高载量组患者血清中IL-18含量高于低载量组,IL-18BP含量低于低载量组;2肝纤维化指标:高载量组患者的透明质酸酶(HA)、层黏连蛋白(LN)、Ⅳ型胶原(ⅣC)、Ⅲ型前胶原(PⅢNP)水平均高于低载量组;3高载量组患者的CD4+T细胞、CD16/65+自然杀伤细胞(NK)含量低于低载量组,CD8+T细胞的含量高于低载量组;4IL-18含量与HA、LN、ⅣC、PⅢNP水平以及CD8+T细胞含量呈正相关(β=2.245~2.654,R=0.458~0.782,t=6.182~8.654,P0.05),与CD4+T细胞、CD16/65+NK细胞含量呈负相关(β=-2.753,-2.648,R=-0.478,-0.532,t=7.032,7.294,P0.05)。结论慢性乙型肝炎患者血清中IL-18含量增高,IL-18BP含量降低,且二者与HBV DNA载量、肝纤维化程度、免疫功能具有良好的相关性。
[Abstract]:Objective to study the relationship between interleukin-18 (IL-18) and its binding protein and the DNA load of hepatitis B virus (HBV) in patients with chronic hepatitis B (CHB).Methods 160 patients with chronic hepatitis B were divided into high load group and low load group according to HBV-DNA load. The content of IL-18 and its binding protein, hepatic fibrosis index and immune function index were measured.Results 1 the serum IL-18 content in the high load group was higher than that in the low load group and the level of IL-18 BP was lower than that in the low load group. The levels of hyaluronidase, laminin, procollagen type 鈪，

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