乙型肝炎病毒感染患者HBV-DNA载量与血清及肝纤维化标志物的关系

发布时间：2018-04-14 12:31

  本文选题：乙型肝炎 + HBV-DNA　； 参考：《中华医院感染学杂志》2017年15期

【摘要】：目的探讨乙型肝炎病毒(HBV)感染患者HBV-DNA载量与血清及肝纤维化标志物的相关性。方法选取2012年1月-2015年12月医院收治的86例HBV感染患者,按照HBV血清标志物分为A组(大三阳)21例、B组(小三阳)35例、C组(除外大小三阳的HBsAg+表型)24例、D组(抗体阳性及全阴)6例,根据HBVDNA载量分为5个级别分为10~3 IU/ml组、10~3~10~5 IU/ml组、10~5~10~6 IU/ml组、10~6~10~8 IU/ml组和10~8IU/ml组。结果 A组HBV-DNA载量显著高于B组和C组,差异有统计学意义(P0.05);C组HBV-DNA载量显著高于B组(P0.05);透明质酸(HA)随着HBV-DNA复制水平的增高而增高,5个不同级别HBV-DNA载量组两两比较差异有统计学意义(P0.05);层粘连蛋白(LN)、Ⅲ型前胶原肽(PⅢP)、Ⅳ型胶原(CⅣ)在10~3IU/ml组、10~3~10~5 IU/ml组、10~5~10~6 IU/ml组中随着患者血清HBV-DNA载量上升也随之递增,而在10~6~10~8 IU/ml组和10~8 IU/ml组中随着血清HBV-DNA载量上升出现相对降低的现象。结论 HBV-DNA载量与HBV血清标志物不同模式组存在相关性,并与LN、PⅢP、CⅣ存在相关性,但不呈直线相关关系,与HA呈正相关。
[Abstract]:Objective to investigate the correlation between HBV-DNA load and serum and hepatic fibrosis markers in patients with hepatitis B virus (HBV) infection.Methods 86 patients with HBV infection were selected from January 2012 to December 2015.According to the serum markers of HBV, group A was divided into two groups: group A (21 cases of large and small yolk) and group B (35 cases of small group C) (with the exception of 24 cases of HBsAg phenotype with the exception of large and small three positive positive and 6 cases of total yin).According to the HBVDNA load, 5 grades were divided into 10 ~ (3) IU/ml group (n = 10), 10 ~ (10) IU/ml group (n = 10) and 10 ~ 10 ~ (6) IU/ml group (n = 10) and 10~8IU/ml group (n = 10).Results the HBV-DNA load of group A was significantly higher than that of group B and group C.The HBV-DNA load of group C was significantly higher than that of group B (P 0.05), and that of hyaluronic acid (HA) increased with the increase of HBV-DNA replication level.Collagen peptide P 鈪，

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