急性胰腺炎短期复发的影响因素研究

发布时间：2018-04-15 18:33

本文选题：胰腺炎 + 复发　；参考：《中国全科医学》2017年08期

【摘要】：目的探讨急性胰腺炎短期复发的危险因素。方法选取2011年5月—2013年12月在南方医科大学附属小榄医院住院的首次发作急性胰腺炎患者130例,经治疗好转出院后,对其进行为期12个月的随访,根据是否出现复发性急性胰腺炎,将患者分为复发组和未复发组。记录两组患者临床资料,分析急性胰腺炎短期复发的危险因素。结果复发组36例,未复发组94例,复发率为27.7%。两组性别、年龄、饮酒率、体质指数(BMI)、胆石症、经内镜逆行性胰胆管造影术(ERCP)检查率、改良CT严重指数(MCTSI)评分、Rason评分、C反应蛋白(CRP)、血清钙、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖水平比较,差异均无统计学意义(P0.05);两组三酰甘油(TG)、餐后2 h血糖水平比较,差异均有统计学意义(P0.05)。多因素Logistic回归分析结果显示,糖耐量受损是急性胰腺炎短期复发的危险因素〔OR=1.473,95%CI(1.027,3.342),P0.05〕。急性胰腺炎合并糖耐量受损者1年复发率为68.8%,未合并糖耐量受损者1年复发率为31.2%,两者复发率比较,差异有统计学意义(χ~2=15.821,P=0.013)。结论糖耐量受损是急性胰腺炎短期复发的独立危险因素,控制急性胰腺炎患者餐后2 h血糖水平可能有助于降低短期复发率。
[Abstract]:Objective to investigate the risk factors of short-term recurrence of acute pancreatitis.Methods from May 2011 to December 2013, 130 patients with acute pancreatitis who were hospitalized in Xiaolan Hospital affiliated to Southern Medical University were followed up for 12 months.Patients were divided into recurrent group and non-recurrent group according to recurrent acute pancreatitis.The clinical data of the two groups were recorded and the risk factors of short-term recurrence of acute pancreatitis were analyzed.Results there were 36 cases in recurrent group and 94 cases in non-recurrence group, the recurrence rate was 27. 7%.Sex, age, alcohol consumption rate, body mass index (BMI), cholelithiasis, endoscopic retrograde cholangiopancreatography (ERCP), modified CT severity index (MCTSI) score, Rason score, C-reactive protein (CRP), serum calcium, and so on.There was no significant difference in fasting blood glucose level between the two groups (P 0.05), but there was no significant difference between the two groups in the level of triacylglycerol (TGG) 2 h after meal. 2 h postprandial blood glucose level was significantly higher than that in the control group (P 0.05).Multivariate Logistic regression analysis showed that impaired glucose tolerance was a risk factor for the short-term recurrence of acute pancreatitis.The recurrence rate of acute pancreatitis complicated with impaired glucose tolerance was 68.8% and that of those without impaired glucose tolerance was 31.2.The difference between the two groups was statistically significant (蠂 ~ 2 = 15.821).Conclusion impaired glucose tolerance is an independent risk factor for the short-term recurrence of acute pancreatitis. The control of 2 h postprandial blood glucose level in patients with acute pancreatitis may help to reduce the short-term recurrence rate.
【作者单位】：南方医科大学附属小榄医院;
【分类号】：R576

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