过敏性疾病对肠易激综合征影响的研究

发布时间：2018-04-16 16:24

  本文选题：肠易激综合征 + 过敏　； 参考：《浙江大学》2017年硕士论文

【摘要】：背景与目的:肠易激综合征(Irritable bowel syndrome,IBS)是一种多因素影响的功能性疾病,其病因和发病机制尚不明确。过敏性疾病与IBS可能存在关联,但研究较少。本研究目的是探讨过敏性疾病对IBS患病率及其临床表现的影响。方法:选取浙江大学医学院附属第二医院2016.11～2017.03至过敏科门诊就诊的患者共108例作为过敏组,其中过敏性鼻炎(AR)患者49例作为AR亚组,荨麻疹(CU)59例作为CU亚组。随机选取本院病房陪护71例作为对照组。比较病例与对照的IBS检出率及其相关胃肠道症状之间的差异,并分析其影响因素。结果:CU组IBS检出率较一般人群有升高趋势(OR=4.644,P=0.078),粪便稀烂程度(P=0.026)和粪便黏滞情况(P=0.015)也更为明显。AR组嗜酸粒细胞(P=0.005)、总免疫球蛋白E(IgE)(P=0.030)较对照组显著增高,户尘螨IgE阳性率较CU组显著升高(P0.001)。过敏组中总IgE与腹胀的发生(OR=3.379,P=0.030)和腹胀严重程度(P=0.036)有关。户尘螨IgE与腹胀的发生有关(OR=3.640,P=0.016),且为腹胀的独立危险因素。结论:CU患者有并发IBS的趋势,且以腹泻为主。过敏性疾病患者总IgE和户尘螨IgE与腹胀的发生和严重程度有关,提示过敏性疾病对胃肠道症状的作用机制可能涉及由IgE介导的免疫反应。户尘螨IgE是腹胀的独立危险因素,提示该过敏原与胃肠道症状的密切联系。
[Abstract]:Background & objective: Irritable bowel syndrome (IBSs) is a multifactorial functional disease, the etiology and pathogenesis of which are unclear.Allergic diseases may be associated with IBS, but less research has been done.The aim of this study was to investigate the effects of allergic diseases on the prevalence and clinical manifestations of IBS.Methods: 108 patients from the second affiliated Hospital of Zhejiang University Medical College were selected as allergic group, 49 patients with allergic rhinitis as AR subgroup and 59 patients with urticaria as CU subgroup.A total of 71 patients were randomly selected as control group.To compare the detection rate of IBS and the difference of gastrointestinal symptoms between cases and controls, and analyze the influencing factors.Results the detection rate of IBS in the 10% CU group was significantly higher than that in the general population (P 0.026) and the viscosity of feces (P 0.026). The positive rate of IBS in the AR group was significantly higher than that in the control group (P 0.005), and the total immunoglobulin IgE (0.030) in the AR group was significantly higher than that in the control group.The positive rate of IgE in dust mites was significantly higher than that in CU group (P 0.001).In allergy group, the total IgE was related to the occurrence of abdominal distention (OR3.379 P0.030) and the severity of abdominal distension (P0.036).IgE was related to the occurrence of abdominal distention and was an independent risk factor of abdominal distension.Conclusion there is a tendency of IBS in patients with% CU, and diarrhea is the main disease.The total IgE and IgE were related to the occurrence and severity of abdominal distension in patients with allergic diseases, suggesting that the mechanism of allergic diseases on gastrointestinal symptoms may be related to the immune response mediated by IgE.IgE is an independent risk factor for abdominal distension, suggesting that the allergen is closely associated with gastrointestinal symptoms.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R574.4
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本文编号：1759722