含呋喃唑酮的四联疗法补救根除幽门螺杆菌的疗效及安全性的Meta分析

发布时间：2018-04-19 02:24

本文选题：呋喃唑酮 + 幽门螺杆菌　；参考：《广西医科大学》2015年硕士论文

【摘要】：目的：评价与常规四联疗法相比,含呋喃唑酮的四联疗法补救根除幽门螺杆菌的疗效及安全性。方法：计算机检索中国知网、中国生物医学文献数据库、维普中文科技期刊数据库、Pubmed、EMBASE、Cochrane,纳入含呋喃唑酮的四联疗法与常规四联疗法对比,补救根除Hp的随机对照试验。采用RevMan5.0软件进行Meta分析,治疗结局(Hp根除率、不良反应发生率)用比值比(Odds ratio, OR)为评价指标,并计算95%可信区间(95%CI)。纳入研究间的异质性采用x 2检验。结果：纳入6个研究,共788例患者,含呋喃唑酮的治疗组396例,常规疗法的对照组392例。Meta分析显示,含呋喃唑酮的四联疗法与常规四联疗法对比,补救根除Hp的根除率更高,按ITT分析时P=0.05,OR=1.83,95% CI (1.00,3.42),按PP分析时P=0.004,0R=1.99,95%CI(1.25,3.17),两组不良反应发生率无统计学意义(P0.05)。结论：与常规四联疗法相比,含呋喃唑酮的四联疗法补救根除Hp的疗效更好,不良反应的发生率无明显差异。
[Abstract]:Objective: to evaluate the efficacy and safety of furazolidone combined therapy for the eradication of Helicobacter pylori.Methods: a computer search was conducted to search the database of Chinese Biomedical Literature, Chinese Journal of Science and Technology, Pubmedmeda EMBASE Cochrane.Compared with the conventional tetralogy of furazolidone, a randomized controlled trial was conducted to remedy the eradication of HP.RevMan5.0 software was used for Meta analysis. The rate of HP eradication and the incidence of adverse reactions were analyzed by RevMan5.0 software. The ratio ratio of odds ratios (ORs) was used as the evaluation index, and 95% confidence interval (95% CI) was calculated.The heterogeneity between the inclusion studies was tested by x 2 test.Results: a total of 788 patients, 396 patients with furazolidone, and 392 patients with conventional therapy (control group) were enrolled in 6 studies. Meta analysis showed that the eradication rate of HP was higher in the quadruple therapy containing furazolidone than in the conventional tetralogy.According to ITT analysis, 1.83 95% CI 1.00 and 3.42% CI, respectively, according to PP analysis, the incidence of adverse reactions in the two groups was not statistically significant (P 0.05), and the incidence of adverse reactions in the two groups was not statistically significant (P < 0.05). The incidence of adverse reactions in the two groups was not significantly higher than that in the control group (P < 0.05), and the incidence of adverse reactions was not significant in the two groups (P < 0.05).Conclusion: compared with conventional tetralogy, the treatment with furazolidone has a better curative effect on HP eradication, and there is no significant difference in the incidence of adverse reactions.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R573

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