细菌感染诱发肝性脑病的乙型肝炎肝硬化患者临床特点分析

发布时间：2018-04-24 07:45

本文选题：乙型肝炎 + 肝硬化　；参考：《山东医药》2015年19期

【摘要】：目的分析细菌感染诱发肝性脑病的乙型肝炎肝硬化患者的临床特点。方法回顾性分析186例乙型肝炎肝硬化合并肝性脑病患者的临床资料,根据是否存在细菌感染的诱因将患者分为感染组(59例)和非感染组(127例)。观察两组血氨、白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、国际标准化比率(INR)、白细胞(WBC)、中性粒细胞百分比、肌酐(Cr)、病死率。结果感染组血氨(113.7±63.0)μmol/L,ALT(206.3±86.4)U/L,TBIL(113.7±62.9)mmol/L,WBC(11.0±7.3)×109/L,中性粒细胞百分比79.6%±6.6%,Cr(118.2±91.4)μmol/L,Child-Pugh分级(13±1)分,病死率为40.6%。非感染组血氨(80.9±40.7)μmol/L,ALT(114.2±20.9)U/L,TBIL(80.9±40.7)mmol/L,WBC(6.6±4.8)×109/L,中性粒细胞百分比61.4%±6.9%,Cr(72.9±34.3)μmol/L,Child-Pugh分级(10±1)分,病死率为28.3%,两组比较,P均0.05。结论细菌感染诱发肝性脑病的乙型肝炎肝硬化患者肝损害重,血氨、WBC、中性粒细胞百分比、病死率高。
[Abstract]:Objective to analyze the clinical characteristics of patients with hepatitis B cirrhosis induced by bacterial infection. Methods the clinical data of 186 patients with hepatitis B cirrhosis complicated with hepatic encephalopathy were analyzed retrospectively. According to the inducement of bacterial infection, the patients were divided into infection group (59 cases) and non-infection group (127 cases). The blood ammonia, albumin, alanine aminotransferase (alt), total bilirubin (TBILL), international standard ratio (INR), WBCU, neutrophil percentage, creatinine (Cr), mortality were observed. Results in the infected group, the blood ammonia levels were 113.7 卤63.0 渭 mol / L, 206.3 卤86.4 渭 mol / L, 113.7 卤62.9 mmol / L, 11.0 卤7.3 脳 10 9 / L, 79.6% 卤6.6Cr118.2 卤91.4 渭 mol / L Child-Pugh Child-Pugh grade (13 卤1), and the mortality was 40.6%. In the non-infected group, the blood ammonia concentration was 80.9 卤40.7) 渭 mol / L (114.2 卤20.9 渭 mol 路L ~ (-1) 渭 mol 路L ~ (-1) 渭 mol 路L ~ (-1) 渭 mol 路L ~ (-1)). The percentage of neutrophilic granulocytes was 61.4% 卤6.9m 路L ~ (-1) 渭 mol 路L 路L ~ (-1). The mortality was 28.3U 路L ~ (-1). Conclusion Hepatitis B cirrhosis patients with hepatic encephalopathy induced by bacterial infection have serious liver damage, blood ammonia, neutrophil percentage and high mortality.
【作者单位】：天津市第三中心医院天津医科大学第三临床学院天津市人工细胞重点实验室天津市肝胆疾病研究所;
【基金】：艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项(2012ZX10002004-011) 天津市科委基金项目(12JCYBJC17300)
【分类号】：R575.2

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