中性粒细胞计数与非酒精性脂肪肝关联性的前瞻性队列研究

发布时间：2018-04-25 17:19

  本文选题：非酒精性脂肪肝 + 中性粒细胞计数　； 参考：《山东大学学报(医学版)》2017年06期

【摘要】：目的探讨中性粒细胞计数与非酒精性脂肪肝(NAFLD)的关联性。方法基于大规模健康管理队列,针对队列基线中无NAFLD的15 463例健康体检对象随访,平均随访时间2.54年,随访结局为发生NAFLD;将基线中性粒细胞计数根据四分位数由低到高划分为4个组段(Q1、Q2、Q3、Q4);采用多元Cox回归计算中性粒细胞计数与NAFLD关联性的相对危险度(HR)。结果随访期间3 846人被诊断为NAFLD。Cox结果显示,以Q1为参照,在调整年龄、性别后,中性粒细胞计数的Q2、Q3、Q4三个组段的HR(95%CI)分别为1.265(1.057,1.514)、1.446(1.214,1.724)、1.605(1.350,1.907),上述基础上再调整谷丙转氨酶和γ-谷酰胺转酞酶后,Q2、Q3、Q4三个组段的HR(95%CI)分别为1.264(1.056,1.512)、1.434(1.202,1.710)、1.582(1.330,1.882),进一步调整血脂四项、空腹血糖、体质量指数(BMI)和高血压后,HR(95%CI)分别为1.181(0.986,1.415)、1.189(0.995,1.420)、1.226(1.026,1.464)。结论中性粒细胞计数是NAFLD发病的独立危险因素。
[Abstract]:Objective to investigate the relationship between neutrophil count and NAF LDD in non-alcoholic fatty liver. Methods based on the large scale health management cohort, 15 463 subjects with no NAFLD in the baseline were followed up with an average follow-up time of 2.54 years. The baseline neutrophil count was divided into 4 groups according to the quartile number from low to high, and the relative risk of neutrophil count and NAFLD correlation was calculated by multivariate Cox regression. Results during the follow-up period, 3 846 patients were diagnosed with NAFLD.Cox. The HR-95CII of the three groups of neutrophil count Q2OQ3Q4 were 1.265U 1.0571.514U 1.4461.2141.724kW 1.6051.3501.907. On the above basis, the HR-95CIs of the three groups Q2Q3Q4 and Q2Q3 / Q4 were 1.2641.264 / 1.051.512U 1.4341.201.21010 / 1.5821.3301.882n, respectively, to further adjust the blood lipids, fasting blood glucose, fasting blood glucose. The body mass index (BMI) and the post hypertension HRM 95 CII were 1.181 ~ 0.9861.415 ~ 1.189 ~ 0.995 ~ 1.420 ~ (-1) ~ 1.226 ~ 1.026 ~ 1.464m ~ (-1), respectively. Conclusion neutrophil count is an independent risk factor for NAFLD.
【作者单位】： 山东大学公共卫生学院生物统计学系;山东大学齐鲁生物医学大数据研究中心;
【基金】：国家自然科学基金(81273177);国家自然科学基金青年基金(81400072) 山东省自然科学基金(2013HQ047)
【分类号】：R575.5
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本文编号：1802247