石家庄地区乙型肝炎病毒基因分型及P区耐药基因突变分析

发布时间：2018-04-25 17:58

本文选题：肝炎 + 乙型　；参考：《中国医院药学杂志》2015年04期

【摘要】：目的:分析石家庄地区乙型肝炎病毒(HBV)基因型分布以及核苷(酸)类似物耐药基因突变状况。方法:对2011年1月—2013年12月在石家庄市五医院就诊的遵医嘱口服核苷(酸)类似物6个月以上的354例慢性乙型肝炎患者进行HBV P区基因序列测定。结果:HBV B型为17例(4.8%),C型为337例(95.2%);共检出突变182例,在B型中检测出有10例突变(58.8%),在C型中检测出有172例突变(51.1%),两组间突变率无显著差别;182例HBV P区存在突变的病例中以rtL180M+rtM204I/V/S联合突变最多,占突变比例24.2%;其次是rtM204I/V/S单位点突变,占突变比例20.3%,这两种突变模式的比例达到44.5%;第3位是rtL180M+rtM204I/V/S再加上其他一个或多个位点的突变,占突变比例12.6%。结论:石家庄地区HBV基因型以C型为主;核苷(酸)类似物耐药基因突变以拉米夫定和替比夫定耐药最常见。
[Abstract]:Aim: to analyze the genotype distribution of hepatitis B virus (HBV) and the mutation of nucleoside (acid) analogue gene in Shijiazhuang area. Methods: from January 2011 to December 2013, 354 patients with chronic hepatitis B (CHB) who were treated with oral nucleoside analogue for more than 6 months were examined for HBV P gene sequence analysis in Shijiazhuang five Hospitals. Results there were 17 cases of type B of HBV-B and 337 cases of type C, and 182 cases of mutation were detected. Ten cases of mutation 58.8% were detected in type B and 172 cases of mutation 51.1% were detected in type C. among the 182 cases with mutation in HBV P region, rtL180M rtM204I/V/S joint mutation was the most, accounting for 24.2%, followed by point mutation of rtM204I/V/S unit. The proportion of the two mutation patterns reached 44.5, and the third was rtL180M rtM204I/V/S plus one or more other mutations, accounting for 12.6. Conclusion: C genotype is the main genotype of HBV in Shijiazhuang and lamivudine and tibivudine are the most common mutations in nucleoside (acid) analogues.
【作者单位】：石家庄市第五医院;河北以岭医院;石家庄市卫生与计划生育委员会;石家庄市裕华区疾病控制预防中心;
【分类号】：R512.62

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