2011—2015年细菌性腹膜炎病原菌分布及耐药性

发布时间：2018-04-26 11:05

本文选题：细菌性腹膜炎 + 病原菌　；参考：《中国感染控制杂志》2017年10期

【摘要】：目的了解细菌性腹膜炎病原菌分布及耐药状况,为临床抗感染治疗提供实验室依据。方法收集徐州医科大学附属医院2011—2015年细菌性腹膜炎患者腹腔积液培养分离的病原菌,对其进行细菌鉴定和药敏试验,分析病原菌分布和耐药情况。结果共收集菌株491株,其中革兰阴性杆菌291株(59.26%),革兰阳性球菌196株(39.92%),真菌4株(0.82%),排名居前5位的病原菌分别为大肠埃希菌(30.14%)、凝固酶阴性葡萄球菌(12.22%)、金黄色葡萄球菌(10.39%)、肺炎克雷伯菌(8.55%)和屎肠球菌(6.52%)。大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌和铜绿假单胞菌对亚胺培南的耐药率分别是4.90%、31.04%、77.28%和26.27%。耐甲氧西林金黄色葡萄球菌(MRSA)检出率为56.02%,耐甲氧西林凝固酶阴性葡萄球菌(MRNCS)检出率为70.02%。结论引起细菌性腹膜炎的病原菌以革兰阴性杆菌为主,大肠埃希菌占首位;病原菌耐药情况严重,应该加强抗菌药物的规范使用,减少耐药菌株的产生。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogenic bacteria in bacterial peritonitis and to provide laboratory evidence for clinical anti-infection therapy. Methods the pathogens isolated from peritoneal effusion of patients with bacterial peritonitis from 2011 to 2015 in affiliated Hospital of Xuzhou Medical University were collected. Bacterial identification and drug sensitivity test were performed to analyze the distribution and drug resistance of the pathogens. Results A total of 491 strains were collected. Among them, 291 strains of Gram-negative bacilli, 196 strains of Gram-positive coccus, 4 strains of fungi, respectively, are Escherichia coli 30.14, coagulase negative Staphylococcus 12.2222, Staphylococcus aureus 10.39, Klebsiella pneumoniae 8.5555 and Enterococcus faecium 6.52B. among them, 291 strains of Gram-negative bacilli, 196 strains of Gram-positive coccus, 4 strains of fungi, and 4 strains of fungi, respectively, are Escherichia coli 30.14, coagulase negative staphylococcus 12.22, Staphylococcus aureus 10.39, Klebsiella pneumoniae 8.5555. The resistance rates of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa to imipenem were 4.90,31.04% and 26.27%, respectively. The positive rates of MRSAs and MRNCSs of methicillin-resistant staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci were 56.02 and 70.02 respectively. Conclusion Gram-negative bacilli are the main pathogenic bacteria causing bacterial peritonitis, Escherichia coli is the first, and the drug resistance of pathogenic bacteria is serious, we should strengthen the standard use of antimicrobial agents and reduce the production of drug-resistant strains.
【作者单位】：徐州医科大学附属医院;
【基金】：国家自然科学基金(81471994)
【分类号】：R446.5;R572.2

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