中药序贯联合标准三联治疗幽门螺杆菌相关性胃溃疡的临床观察

发布时间：2018-04-26 14:51

本文选题：中药序贯 + 标准三联疗法　；参考：《时珍国医国药》2015年12期

【摘要】：目的观察中药序贯联合标准三联治疗幽门螺杆菌(HP)相关性胃溃疡的临床疗效。方法将HP相关性胃溃疡120例患者随机分为两组,对照组(60例)予标准三联疗法为主治疗,治疗组(60例)在三联基础上加以中药分期序贯治疗,观察两组治疗前后中医证候、临床疗效及远期HP、溃疡复发等疗效及安全性分析。结果治疗组的证候显效率、总有效率分别为93.3%、98.3%,明显优于对照组66.7%、88.3%(P0.01);胃镜显效率、总有效率分别为83.3%、96.7%明显优于对照组61.7%、88.3%(P0.05);证候总积分及改善积分差比较亦明显优于对照组(P0.01);治疗组HP根除率及HP、溃疡复发率分别为93.3%、7.69%、3.85%,明显优于对照组78.3%、37.5%、31.25%(P0.05)。结论中药序贯联合标准三联治疗HP相关性胃溃疡疗效显著,值得深入研究并临床推广应用。
[Abstract]:Objective to observe the clinical effect of sequential Chinese medicine combined with standard triple therapy in the treatment of gastric ulcer associated with Helicobacter pylori (HP). Methods 120 patients with HP associated gastric ulcer were randomly divided into two groups: the control group (n = 60) was treated with standard triple therapy, the treatment group (n = 60) was treated with traditional Chinese medicine by stages on the basis of triple therapy, and the syndromes of traditional Chinese medicine (TCM) were observed before and after treatment. Clinical efficacy and long-term HP, ulcer recurrence and other efficacy and safety analysis. Results the effective rate of syndromes in the treatment group was 93.3% and 98.3%, respectively, which was significantly better than that in the control group (66.7%, 88.3%, P 0.01), and the effective rate of gastroscopy was significantly higher than that of the control group (P 0.01). The total effective rate of 83.3% was significantly better than that of the control group (61.7%), the total score of syndromes and improvement of integral difference were significantly better than that of the control group (P 0.01), the eradication rate of HP and the rate of recurrence of HP and ulcer in the treatment group were 93.33.69% and 3.85% respectively, which were obviously better than the control group (78.3%) and the control group (78.3%). Conclusion Sequential Chinese medicine combined with standard triple therapy is effective in the treatment of HP-associated gastric ulcer, which is worthy of further study and clinical application.
【作者单位】：山东中医药大学第一临床学院;山东中医药大学附属医院;
【基金】：山东省研究生教育创新计划立项项目山东省中医药科技发展计划项目
【分类号】：R573.1

【参考文献】