多药耐药基因MDR1 C3435T基因多态性对质子泵抑制剂三联方案根除幽门螺杆菌疗效影响的Meta分析

发布时间：2018-05-01 00:23

本文选题：多药耐药基因 + MDR　；参考：《中国药房》2017年33期

【摘要】：目的:系统评价多药耐药基因MDR1 C3435T基因多态性与质子泵抑制剂三联方案根除幽门螺杆菌疗效的关系,为临床提供循证参考。方法:计算机检索Pub Med、EMBase、中国生物医学文献数据库(CBM)、相关期刊论文(CJFD)、万方数据库、中文科技期刊数据库(VIP),收集MDR1 C3435T基因多态性对质子泵抑制剂三联方案根除幽门螺杆菌感染疗效的临床研究,提取资料并按照STREGA声明评价质量,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入7项研究,合计1 019例患者。按照患者MDR1 C3435T基因型检测结果分为野生纯合子基因(CC)型组,突变杂合子基因(CT)型组与突变纯合子基因(TT)型组。Meta分析结果显示,MDR1 C3435T基因多态性中CC组、CT组与TT组患者幽门螺杆菌根除率比较,差异均无统计学意义[CC vs.CT:OR=0.99,95%CI(0.69,1.42),P=0.95;CC vs.TT:OR=1.44,95%CI(0.66,3.15),P=0.36;CT vs.TT:OR=1.54,95%CI(0.86,2.73),P=0.14];亚组分析发现,亚洲人群中CT组患者幽门螺杆菌根除率显著高于TT组,差异有统计学意义[OR=2.35,95%CI(1.53,3.62),P0.001]。结论:MDR1 C3435T基因多态性基本不影响质子泵抑制剂三联方案根除幽门螺杆菌的疗效,但亚洲人群进行治疗时,参考基因检测结果有一定意义。
[Abstract]:Objective: to evaluate the relationship between the polymorphism of multidrug resistance gene MDR1 C3435T and the efficacy of proton pump inhibitor triple regimen in the eradication of Helicobacter pylori. Methods: a computerized search was conducted for Pub Meden EMBase, China Biomedical Literature Database (CBM), China Journal Full-text Database (CJFDE), and Wanfang Database. The clinical study of MDR1 C3435T gene polymorphism on proton pump inhibitor triple regimen for the eradication of Helicobacter pylori infection was carried out. The data were extracted and the quality was evaluated according to the STREGA statement. The Meta analysis was carried out by Rev Man 5.3 statistical software. Results: a total of 1 019 patients were included in 7 studies. According to the results of MDR1 C3435T genotypes, the patients were divided into wild homozygous gene group. Meta-analysis showed that there was no significant difference in the eradication rate of Helicobacter pylori between CC group and TT group in the polymorphism of MDR1 C3435T gene. The eradication rate of Helicobacter pylori in CT group was significantly higher than that in TT group (P 0.001). Conclusion the effect of proton pump inhibitor triple regimen on the eradication of Helicobacter pylori is not affected by the gene polymorphism of the 10% MDR1 C3435T gene.
【作者单位】：乐山市人民医院;
【基金】：四川省医学科研青年创新课题(No.Q16035)
【分类号】：R573

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