肝硬化甲状腺激素的变化研究及临床意义分析

发布时间：2018-05-01 06:28

本文选题：肝硬化 + 甲状腺激素　；参考：《浙江大学》2017年硕士论文

【摘要】：目的:研究肝硬化患者甲状腺激素水平的变化,及与Child-Pugh分级、MELD评分之间的关系,评估肝硬化患者的肝功能与甲状腺激素水平的关系,探讨甲状腺激素水平在肝硬化进展及诊治中的临床意义。方法:对2015年1月到2017年1月浙江大学附属第一医院住院的212例肝硬化患者进行统计分析,并选取40名同期健康体检者作为对照组,比较两组的血清甲状腺激素水平。结果:不同病因的肝硬化患者的血清甲状腺激素水平无统计学差异;代偿期肝硬化与失代偿期肝硬化仅在血清TT3、FT3水平上有显著差异(P0.05);肝硬化患者Child-Pugh分级各组的血清TSH水平间无显著性差异;在血清TT3水平上,对照组Child B 组Child C 组(P0.01),Child A 级Child B 组Child C 组(P0.05);在血清FT3、TT4水平上,对照组Child A组Child B组(P0.05),对照组Child A组Child C组(P0.05);对照组和Child C组的血清FT4水平均高于ChildA组、B组;血清TT3、FT3水平与Child-Pugh评分、MELD评分均呈显著的强的负相关关系。结论:血清甲状腺激素对肝硬化患者病情严重程度的判断及预后的预测均有一定临床价值,可以用于协助对肝硬化程度的判断和预后的评估。
[Abstract]:Objective: to study the changes of thyroid hormone levels in patients with liver cirrhosis and the relationship between thyroid hormone levels and Child-Pugh grading and meld scores. To investigate the clinical significance of thyroid hormone level in the diagnosis and treatment of liver cirrhosis. Methods: 212 patients with liver cirrhosis hospitalized in the first affiliated Hospital of Zhejiang University from January 2015 to January 2017 were statistically analyzed and 40 healthy persons were selected as control group. The serum thyroid hormone levels were compared between the two groups. Results: there was no significant difference in serum thyroid hormone levels in patients with liver cirrhosis with different etiology. There was only a significant difference in serum TT3 FT 3 level between compensatory cirrhosis and decompensated cirrhosis (P 0.05). There was no significant difference in serum TSH level between Child-Pugh grading groups and serum TT3 level in patients with liver cirrhosis. In control group, Child B group, Child C group, control group Child A group Child B group, control group Child A group Child C group P 0.05, serum FT4 level in control group and Child C group were higher than that in ChildA group B group, and the levels of serum FT4 in control group Child A group were higher than those in ChildA group B group. There was a significant negative correlation between serum TT 3 FT 3 level and Child-Pugh score and meld score. Conclusion: serum thyroid hormone has certain clinical value in predicting the severity and prognosis of liver cirrhosis, and can be used to evaluate the severity and prognosis of cirrhosis.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R575.2

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