射频消融术治疗Barrett食管疗效的meta分析

发布时间：2018-05-01 23:12

本文选题：Barrett食管 + 射频消融术　；参考：《重庆医科大学》2014年硕士论文

【摘要】：目的：射频消融术(RFA)是一种应用于治疗Barrett食管（BE）的新兴内镜技术本研究根据RFA术后患者的异型增生完全根除（CE-D）和肠上皮化生的完全根除（CE-IM）等指标，评价RFA治疗BE患者的有效性和持久性方法：通过计算机检索Pubmed Medline CNKI万方等数据库，经过严格的纳入排除标准搜集文献，提取其中有效数据，计算出接受RFA的BE患者的CE-IM和CE-D率以及治疗成功后肠上皮化生（IM）复发率，应用stata12.0软件进行合并数据及进行统计学分析，计算不良事件发生率结果：纳入研究共7篇（包括2477个样本）评价治疗效率，其中有4篇（171个样本）评价了持久性患者达到CE-IM为84%（95%CI=0.74-0.94），，CE-D为85%（95%CI=0.78-0.93），治疗患者病情进展为腺癌由其他级别的BE进展为HGD的比率为8%（95%CI=-0.03-0.2）,治疗达到CE-IM的患者，肠上皮化生复发率为11%（95%CI=0.04-0.18）食管狭窄是最常见的不良事件，发生率为9%（95%CI=0.04-0.13）结论： RFA治疗Barrett食管患者所达到完全根除异型增生和肠化生的患者的比率较高，仅有少量的患者成功根除IM后出现肠上皮化生复发，治疗中的不良事件发生率较低，所以RFA治疗BE是安全有效并且持久的
[Abstract]:Objective: Radiofrequency ablation (RF) is a new endoscopic technique for the treatment of Barrett's esophagus. This study was designed to evaluate the efficacy and persistence of RFA in the treatment of patients with be according to the criteria of complete eradication of dysplasia (CE-D-) and complete eradication of intestinal metaplasia (CE-IMN) after RFA. Methods: The database of Pubmed Medline CNKI Wanfang and so on were searched by computer. The valid data were extracted through strict inclusion of exclusion criteria. The rates of CE-IM and CE-D in be patients receiving RFA and the recurrence rate of intestinal metaplasia after successful treatment were calculated. Combining data and statistical analysis with stata12.0 software to calculate the incidence of adverse events Results: A total of 7 articles (including 2, 477 samples) were included in the study to evaluate the efficacy of treatment. Of these, four (171 samples) evaluated the percentage of persistent patients who had reached CE-IM 84 / 95 and whose CE-D was 85 / 95CI0.78-0.93. The rate of progression from other levels of be to HGD was 8 / 95CI-0.03-0.2for patients who had been treated with CE-IM. The recurrence rate of intestinal metaplasia is 1195% CIQ 0.04-0.18) esophageal stenosis is the most common adverse event, and the incidence is 9% 95% CIQ 0.04-0.13) Conclusion: The rate of complete eradication of dysplasia and intestinal metaplasia was higher in patients with Barrett esophagus treated with RFA. Only a small number of patients had recurrence of intestinal metaplasia after successful eradication of IM, and the incidence of adverse events in treatment was lower. So RFA is safe, effective and persistent in treating be.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R571

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