化浊解毒愈肠方联合美沙拉嗪治疗溃疡性结肠炎的临床观察

发布时间：2018-05-02 05:53

本文选题：溃疡性结肠炎 + 泄泻　；参考：《河北医科大学》2017年硕士论文

【摘要】：目的:观察化浊解毒愈肠方联合美沙拉嗪治疗溃疡性结肠炎的临床疗效方法:将符合纳入标准的60例溃疡性结肠炎患者,按随机数字表法分为治疗组和对照组,各组30例。两组患者在性别、年龄、病程、病情严重程度、症状、体征等方面均无统计学差异。治疗组予以化浊解毒愈肠方口服联合美沙拉嗪肠溶片口服治疗,对照组予以美沙拉嗪肠溶片口服治疗,2周1个疗程,连续服用为2个疗程,治疗结束6个月后随访,观察两组治疗前后的总疗效、主要症状体征、结肠镜下黏膜的变化及不良反应和复发的情况。结果:1两组总体疗效比较,治疗组总有效率90%。对照组总有效率83.3%;两组比较经秩和检验,P0.05,具有统计学意义,表明治疗组综合疗效优于对照组。2两组腹泻、黏液脓血便、腹痛、里急后重等主要症状疗效比较治疗组与对照组组内治疗前与治疗后比较,采用秩和检验,P0.05,均有统计学意义,表明两组治疗均有效。治疗后,治疗组与对照组组间比较,经秩和检验,P0.05,具有统计学意义,治疗组疗效优于对照组。3治疗后两组肠镜下黏膜病变改善的比较治疗组和对照组组内比较,治疗组在治疗前后比较,采用秩和检验,P0.05,有统计学意义,治疗组治疗有效,对照组在治疗前后比较,采用秩和检验,P0.05,无统计学意义。治疗后,治疗组与对照组组间比较,经秩和检验,P0.05,具有统计学意义,治疗组在改善镜下黏膜病变方面优于对照组。4不良反应及复发情况比较,两组治疗期间均无不良反应发生,治疗结束6个月随访,治疗组复发1例,对照组复发6例。结论:通过本项临床观察,治疗组和对照组对溃疡性结肠炎均有治疗效果,从腹泻、黏液脓血、腹痛等症状体征来评价,中药化浊解毒愈肠方加减口服治疗溃疡性结肠炎有明显的疗效,且中药化浊解毒愈肠方加减口服加美沙拉嗪口服治疗溃疡性结肠炎的临床疗效明显优于单用美沙拉嗪,且可有效防止溃疡性结肠炎的复发,在临床治疗中是切实可行的方法。
[Abstract]:Objective: to observe the clinical efficacy of Huazhuojiedu Yuchang recipe (Huazhujiedu Yuchang decoction) combined with mesalazine in the treatment of ulcerative colitis. Methods: 60 patients with ulcerative colitis were divided into treatment group (n = 30) and control group (n = 30). There were no significant differences in sex, age, course, severity, symptoms and signs between the two groups. The treatment group was treated with Huazhuojiedu Yuchang decoction and mesalazine enteric-coated tablets orally, while the control group was treated with mesalazine enteric-coated tablets for 2 weeks and 2 consecutive courses of treatment, followed up for 6 months after the end of the treatment. The total curative effect, main symptoms and signs, mucosal changes under colonoscopy, adverse reactions and recurrence were observed before and after treatment. Results compared with the two groups, the total effective rate of the treatment group was 90%. The total effective rate of the control group was 83.3%, the comparison of the two groups by rank sum test (P0.05) had statistical significance, which indicated that the comprehensive curative effect of the treatment group was better than that of the control group (group .2) with diarrhea, mucus, blood stool and abdominal pain. Comparison of curative effect between the treatment group and the control group before and after treatment, the rank sum test was used to test P0.05, all of which had statistical significance, indicating that the treatment was effective in both groups. After treatment, the comparison between the treatment group and the control group showed that the rank sum test showed that the curative effect of the treatment group was better than that of the control group (P 0.05), and the curative effect of the treatment group was better than that of the control group (P < 0.05), and the comparison between the treatment group and the control group was better than that in the control group. Compared before and after treatment, the treatment group was treated with rank sum test (P 0.05), the treatment group was effective, and the control group was compared before and after treatment with rank sum test (P 0.05), which had no statistical significance. After treatment, compared with the control group, the rank sum test (P 0.05) was statistically significant. The treatment group was superior to the control group in improving the pathological changes of mucosa under microscope. At the end of 6 months follow-up, 1 case in the treatment group and 6 cases in the control group. Conclusion: both the treatment group and the control group have therapeutic effects on ulcerative colitis through the clinical observation. The symptoms and signs of diarrhea, mucus abscess, abdominal pain and so on are evaluated. The Chinese medicine Huazhuo jiedu Yuchang decoction plus and subtractive oral treatment of ulcerative colitis has obvious curative effect, and the clinical curative effect of traditional Chinese medicine Huazhuo jiedu Yuchang prescription plus subtractive oral mesalazine oral in the treatment of ulcerative colitis is obviously better than that of single mesalazine alone in the treatment of ulcerative colitis. It can effectively prevent the recurrence of ulcerative colitis and is a feasible method in clinical treatment.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R574.62

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