西宁地区非酒精性脂肪肝患者nesfatin-1水平变化及临床意义研究

发布时间：2018-05-02 23:16

本文选题：非酒精性脂肪性肝病 + 单纯性脂肪肝　；参考：《青海大学》2017年硕士论文

【摘要】：目的:通过检测西宁地区非酒精性脂肪肝(nonalcoholic simple fatty liver diease,NAFLD)患者血清nesfatin-1水平,研究nesfatin-1与NAFLD之间的关系,同时进一步探讨NAFLD的发病机制,为西宁地区NAFLD的预防及治疗提供一定的临床资料。方法:选取2016年1月至2016年8月在青海大学附属医院体检中心确诊为NAFLD的患者59例(单纯性脂肪性肝30例、脂肪性肝炎29例)作为研究对象,选取同期到我院体检中心健康体检者30例为对照组;收集体重指数、转氨酶、血脂等指标;用酶联免疫吸附法检测血清nesfatin-1水平;均行腹部彩超检查;比较三组间的差异以及血清nesfatin-1水平与各指标之间的相关性。结果:(1)非酒精脂肪性肝组体重指数、谷丙转氨酶、甘油三酯水平高于对照组,有统计学差异(P0.05);脂肪性肝炎组的谷丙转氨酶、甘油三酯水平高于单纯性脂肪肝组,有统计学差异(P0.05);(2)脂肪肝组nesfatin-1水平低于对照组,有统计学差异(P0.05);(3)脂肪性肝炎组nesfatin-1水平低于单纯性脂肪肝组,有统计学差异(P0.05);(4)脂肪肝组中nesfatin-1水平与体重指数、甘油三酯呈负相关(r=-0.307,r=-0.383,P0.05),与谷丙转氨酶均无明显相关性;(5)logistic回归分析结果提示nesfatin-1水平的下降为NAFLD发生的独立危险因素(OR=1.43,P0.05)。结论:(1)西宁地区非酒精性脂肪肝患者存在着体重超重、肝功异常、脂代谢紊乱情况,随着病情进展,上述指标明显异常;(2)西宁地区非酒精性脂肪肝患者血清nesfatin-1水平较正常人低,nesfatin-1水平与体重指数、甘油三酯呈负相关,且随着患者病情进展,nesfatin-1水平逐渐降低;(3)血清nesfatin-1水平可作为预测非酒精性脂肪肝发生的独立危险因素,是非酒精性脂肪肝早期诊断和判断病情严重程度的一个重要指标,可尝试在临床工作中可加以推广及应用。
[Abstract]:Objective: to study the relationship between nesfatin-1 and NAFLD by detecting the level of serum nesfatin-1 in patients with nonalcoholic fatty liver disease (NAF LDD) in Xining, and to explore the pathogenesis of NAFLD. To provide some clinical data for the prevention and treatment of NAFLD in Xining area. Methods: from January 2016 to August 2016, 59 patients (30 cases of simple fatty liver and 29 cases of fatty hepatitis) who were diagnosed as NAFLD in the physical examination center of affiliated Hospital of Qinghai University were selected as the study subjects. 30 healthy persons from the same period were selected as control group, body mass index, transaminase and blood lipid were collected, serum nesfatin-1 levels were detected by enzyme-linked immunosorbent assay (Elisa), abdominal color ultrasound was performed. The differences among the three groups and the correlation between the serum nesfatin-1 level and the indexes were compared. Results the body mass index (BMI), alanine aminotransferase (alt) and triglyceride (TG) levels in non-alcoholic fatty liver group were higher than those in control group (P 0.05), and the levels of alanine aminotransferase and triglyceride in fatty hepatitis group were higher than those in simple fatty liver group. The level of nesfatin-1 in fatty liver group was lower than that in control group, and the level of nesfatin-1 in fatty hepatitis group was lower than that in simple fatty liver group, and there was statistical difference in nesfatin-1 level and body mass index in fatty liver group. There was a negative correlation between triglyceride and glutamate-pyruvic transaminase. The results of logistic regression analysis showed that the decrease of nesfatin-1 level was an independent risk factor for the occurrence of NAFLD. Conclusion (1) Non-alcoholic fatty liver patients in Xining area have overweight, abnormal liver function and disorder of lipid metabolism. The serum nesfatin-1 level of non-alcoholic fatty liver patients in Xining area was lower than that of normal controls. The serum nesfatin-1 level was negatively correlated with body mass index (BMI) and triglyceride (TG). The serum nesfatin-1 level could be used as an independent risk factor to predict the occurrence of non-alcoholic fatty liver, and it was an important index to diagnose and judge the severity of non-alcoholic fatty liver in the early stage. It can be tried to be popularized and applied in clinical work.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R575.5

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