奥曲肽联合前列地尔治疗急性胰腺炎的meta分析

发布时间：2018-05-03 02:01

  本文选题：奥曲肽 + 前列地尔　； 参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:系统评价奥曲肽联合前列地尔治疗急性胰腺炎(acute pancreatitis,AP)的安全性及有效性。方法:计算机检索PubMed、CBM、CNKI、VIP、万方数据库,查找有关应用奥曲肽联合前列地尔治疗急性胰腺炎的随机对照实验(randomized controlled trials,RCTs),同时查找符合要求文献的引用文献,检索时间限制:自数据库建立到2015年10月。2名研究人员各自筛选相关研究,同时提取所需资料及评价相关研究的质量,用RevMan 5.2软件分析。结果:符合要求的研究18个,共计1277个患者。进行Meta分析后,其结果如下:在常规治疗+奥曲肽的基础上,加用前列地尔在以下方面效果更佳,其差异具有统计学意义:总有效率[RR=1.20,95%CI(1.15,1.26)],腹部症状缓解时间[SMD= 2.68,95%CI( 3.11, 2.25)],腹部体征缓解时间[SMD= 2.54,95%CI( 2.79, 2.30)],血淀粉酶恢复正常时间[SMD= 1.95,95%CI( 2.15, 1.76)],并发症发生率[RR=0.30,95%CI(0.13,0.69)],平均住院时间[SMD= 8.95,95%CI( 13.61, 4.29)]。结论:本研究结果显示,在奥曲肽的基础上,加用前列地尔效果更佳,为急性胰腺炎的治疗提供了新的选择。但本Meta分析纳入研究的病例总数较少,且大多数研究质量偏低,所以本研究所得出的结论需更多高质量的研究加以验证。
[Abstract]:Objective: to evaluate the safety and efficacy of octreotide combined with alprostadil in the treatment of acute pancreatitis (AP). Methods: a computer-based search was made for the database of PubMedus CBM, CNKI, VIP, Wanfang. The randomized controlled trial of octreotide combined with alprostadil in the treatment of acute pancreatitis was conducted, and the citations of the required literatures were also found at the same time. Search time limit: from the establishment of the database to October 2015, 2. 2 researchers screened the relevant research, simultaneously extracted the required data and evaluated the quality of the related research, and analyzed it with RevMan 5.2 software. Results: a total of 1277 patients were enrolled in 18 studies. The results of Meta analysis were as follows: on the basis of routine treatment of octreotide, prostadil was more effective in the following aspects. 鍏跺樊寮傚叿鏈夌粺璁″�︽剰涔�:鎬绘湁鏁堢巼[RR=1.20,95%CI(1.15,1.26)],鑵归儴鐥囩姸缂撹В鏃堕棿[SMD= 2.68,95%CI( 3.11, 2.25)],鑵归儴浣撳緛缂撹В鏃堕棿[SMD= 2.54,95%CI( 2.79, 2.30)],琛，

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