血红素加氧酶-1及其产物在肝病中的作用及其机制

发布时间：2018-05-05 12:50

本文选题：血红素加氧酶- + 病毒性肝炎　；参考：《中国药理学与毒理学杂志》2016年02期

【摘要】：血红素加氧酶(HO)是降解血红素成为一氧化碳(CO)、铁离子和胆绿素过程中的限速酶,其亚型HO-1的诱导、超表达或抑制降解可显著抑制乙肝和丙肝病毒复制,改善肝急/慢性炎症及纤维化。HO-1及其代谢产物通过抗炎、抗氧化和抗凋亡作用与细胞保护密切相关,能改善多种因素引起的肝损伤,并对缺血再灌注损伤、急/慢性免疫排斥反应及肝移植生存率均有改善作用。HO-1在肿瘤细胞中过表达,抑制HO-1表达能促进肝癌细胞凋亡、减缓肝癌生长及其血管生成,提示它可能是肝癌治疗的潜在靶点。本文分析了HO-1及其产物在病毒性肝炎、肝损伤、肝纤维化、肝移植和肝癌中的作用及其机制,旨在阐明HO-1的靶点特性。鉴于HO-1具有显著的抗病毒、抗炎和保肝作用,且抑制HO-1表达能抑制肝癌生长,故靶向HO-1可能成为临床治疗肝病及新药研发的一种新策略。
[Abstract]:Heme oxygenase (HOH) is a rate-limiting enzyme in the process of degradation of heme into carbon monoxide, iron ions and gallbladdins. The induction, overexpression or inhibition of degradation of HO-1 subtype of heme oxygenase can significantly inhibit the replication of hepatitis B and hepatitis C virus. Ameliorating acute / chronic inflammation of liver and fibrosis. HO-1 and its metabolites are closely related to cell protection through anti-inflammatory, anti-oxidative and anti-apoptotic effects. Both acute / chronic immune rejection and survival rate of liver transplantation were improved. HO-1 was overexpressed in tumor cells. Inhibiting the expression of HO-1 could promote the apoptosis of hepatoma cells and slow down the growth and angiogenesis of HCC. It suggests that it may be a potential target for the treatment of liver cancer. The role and mechanism of HO-1 and its products in viral hepatitis, liver injury, liver fibrosis, liver transplantation and liver cancer were analyzed in order to elucidate the target characteristics of HO-1. In view of the obvious antiviral, anti-inflammatory and hepatoprotective effects of HO-1, and the inhibition of HO-1 expression can inhibit the growth of liver cancer, targeted HO-1 may become a new strategy for clinical treatment of liver diseases and the development of new drugs.
【作者单位】：中国计量大学生命科学学院药学系浙江省生物计量及检验检疫技术重点实验室;
【基金】：浙江省自然科学基金(LY14H310010) 教育部科技研究重点项目(212073)~~
【分类号】：R575

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