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老年肠易激综合征患者肠黏膜肥大细胞与血管活性肠肽的表达及意义

发布时间:2018-05-05 18:40

  本文选题:肠易激综合征 + 肥大细胞 ; 参考:《中国老年学杂志》2017年03期


【摘要】:目的探讨肠易激综合征(IBS)患者肠黏膜肥大细胞(MC)及血管活性肠肽(VIP)的表达及其可能作用。方法 33例腹泻型IBS患者(D-IBS组)、27例便秘型IBS患者(C-IBS组)及18例健康体检者(对照组)纳入研究。分别取回盲部、乙状结肠黏膜行VIP免疫组织化学染色和甲苯胺蓝染色MC计数,检测肛管直肠压力。结果 1D-IBS组和C-IBS组乙状结肠部MC计数均较回盲部显著降低(P0.05),两组间各部MC计数比较无统计学差异(P0.05),但各部位均较对照组显著增高(P0.05)。2D-IBS组和C-IBS组回盲部和乙状结肠黏膜VIP表达无统计学差异(P0.05),但各部位均较对照组显著增高(P0.05)。3三组间静息压、最大收缩压及松弛压均无统计学差异(P0.05)。D-IBS组和C-IBS组患者感觉阈值、最大容量阈值及疼痛阈值均无统计学差异(P0.05),但与对照组比较均显著降低(P0.05)。结论 IBS患者结肠黏膜MC和VIP表达增加,可能对IBS患者内脏高敏感性的形成有一定影响。
[Abstract]:Objective to investigate the expression and possible role of mast cell (MC) and vasoactive intestinal peptide (VIP) in intestinal mucosal mast cells in patients with irritable bowel syndrome (IBS). Methods Twenty-seven patients with constipated IBS (n = 27) and 18 healthy controls (n = 18) were enrolled in the study in D-IBS group (n = 33) and control group (n = 18). VIP immunohistochemical staining and toluidine blue staining were performed to measure the anorectal pressure. Results the count of MC in sigmoid colon in 1D-IBS group and C-IBS group was significantly lower than that in ileocecal part. There was no significant difference in MC count between the two groups. However, there was a significant increase in the ileocecal part and sigmoid mucocolon between 1D-IBS group and C-IBS group. 2D-IBS group and C-IBS group were significantly higher than the control group in ileocecal part and sigmoid colonic mucocolon count. There was no significant difference in the expression of VIP between the three groups, but the resting pressure of the three groups was significantly higher than that of the control group. There was no significant difference in maximum systolic blood pressure and relaxation pressure between P0.05 and D-IBS groups and C-IBS group. There was no significant difference in the threshold of sensation, maximum volume and pain between the two groups (P 0.05), but it was significantly lower than that in the control group. Conclusion the increased expression of MC and VIP in colon mucosa of IBS patients may have an effect on the formation of visceral hypersensitivity in IBS patients.
【作者单位】: 惠州市中医医院消化内二科;惠州市中医医院心内六科;
【分类号】:R574.4

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