磁共振体素内不相干运动和扩散峰度成像在肝纤维化诊断中的价值

发布时间：2018-05-06 12:57

本文选题：体素内不相干运动 + 扩散峰度成像　；参考：《中国老年学杂志》2017年03期

【摘要】：目的初步评价体素内不相干运动(IVIM)和扩散峰度成像(DKI)的参数在肝纤维化病变分期中的临床应用价值。方法收集经病理证实为不同分期的肝纤维化患者35例,男22例,女13例,年龄42~73岁,中位年龄59岁;选取15例健康志愿者,男10例,女5例,年龄30~60岁,中位年龄45岁。应用PHILIPS 3.0T扫描仪,采用头先进仰卧位呼吸门控触发,IVIM模型b值设定为0、25、50、75、100、150、200、300、400、600和800 s/mm~2,DKI模型b值设定为0、500、1 000、1 500及2 000 s/mm~2。分别计算相关参数,通过方差分析及q检验比较各参数在不同级别肝纤维化患者及正常志愿者间的差异,比较IVIM及DKI在肝纤维化诊断中的价值。结果 IVIM-D值在各级肝纤维化中存在显著差异(P0.05),IVIM-f在各级肝纤维化中存在显著差异(P0.01),IVIM-D*在各级肝纤维化中无统计学差异(P=0.128)。DKI-MD值在各级肝纤维化中无统计学差异(P=0.062),但随着肝硬化的进展,MD有逐渐下降的趋势,DKI-MK值在各级肝纤维化中存在统计学差异(P0.05)。结论 IVIM及DKI可以作为无创性的磁共振新技术,较早且准确地反映肝纤维化过程中病理生理改变及组织微观结构的变化。
[Abstract]:Objective to evaluate the clinical value of the parameters of IVIMI and DKI in the staging of hepatic fibrosis. Methods 35 patients with hepatic fibrosis, 22 males and 13 females, aged 42 to 73 years, with a median age of 59 years, were collected from 35 patients with hepatic fibrosis confirmed by pathology, and 15 healthy volunteers, 10 males and 5 females, aged 30 to 60 years, with a median age of 45 years, were selected. By using PHILIPS 3.0T scanner, the b value of PHILIPS model b was set to 0 2550U 75100150 200300400600 and 800s / mm / 2 DKI model b = 0500s-1 000 and 2 000 s / mm / mm2 / m ~ 2 respectively by using the head advanced supine position respiratory gating trigger model b value set to 0 / 2550 / 7510 / 150 / 200300400600 and 800 s / r / mm / 2 DKI model b respectively. The correlation parameters were calculated, and the difference of each parameter between the patients with liver fibrosis and normal volunteers was compared by ANOVA and Q test, and the value of IVIM and DKI in the diagnosis of hepatic fibrosis was compared. Results there was significant difference in IVIM-D value in all levels of liver fibrosis. There was no significant difference in IVIM-D value between different levels of liver fibrosis. DKI-MD was not significantly different in all levels of liver fibrosis, but with the liver fibrosis, there was no significant difference in P0.062, but with the liver fibrosis, there was no significant difference in the value of P0. 128% .DKI-MD in all levels of liver fibrosis, but with the liver fibrosis, there was no significant difference in P0. 062. The development of sclerosis and MD decreased gradually. There was a significant difference in DKI-MK values in liver fibrosis at all levels (P 0.05). Conclusion IVIM and DKI can be used as new noninvasive magnetic resonance imaging techniques to reflect the pathophysiological changes and microstructural changes in liver fibrosis early and accurately.
【作者单位】：吉林大学中日联谊医院放射线科;
【基金】：国家自然科学基金项目(81501459) 吉林省科技厅科技发展计划项目(140520020JH) 吉林省教育厅十三五科学技术研究项目〔吉教科合字(2016)第467号〕
【分类号】：R445.2;R575.2

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