雷贝拉唑治疗慢性萎缩性胃炎的临床疗效及其对血清胃泌素和内皮素水平的影响研究

发布时间：2018-05-06 22:31

本文选题：胃炎 + 萎缩性　；参考：《中国全科医学》2017年S1期

【摘要】：目的探讨雷贝拉唑治疗慢性萎缩性胃炎(CAG)的临床疗效及其对血清胃泌素(GAS)和内皮素(ET)水平的影响。方法选取2015年3月—2017年1月信阳市中心医院收治的CAG患者150例,采用随机数字表法分为对照组和观察组,每组75例。两组患者均常规服用左氧氟沙星和呋喃唑酮片,在此基础上,对照组患者加服奥美拉唑镁肠溶片,观察组患者加服雷贝拉唑钠肠溶胶囊。比较两组患者的临床疗效、治疗前后血清GAS和ET水平、幽门螺杆菌根除率、不良反应发生率。结果观察组患者临床疗效优于对照组(P0.05)。治疗前两组患者血清GAS和ET水平比较,差异无统计学意义(P0.05);治疗后观察组患者血清GAS水平高于对照组,血清ET水平低于对照组(P0.05)。观察组患者幽门螺杆菌根除率高于对照组(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论雷贝拉唑治疗CAG的临床疗效确切,可明显提高患者血清GAS水平,降低ET水平,安全性良好。
[Abstract]:Objective to investigate the clinical efficacy of rabeprazole in the treatment of chronic atrophic gastritis (CAG) and its effect on serum gastrin gastrin (gastrin) and endothelin (et) levels. Methods 150 patients with CAG were selected from Xinyang Central Hospital from March 2015 to January 2017. They were randomly divided into control group and observation group with 75 cases in each group. Levofloxacin and furazolidone tablets were routinely taken in both groups. On this basis, the patients in the control group were given omeprazole magnesium enteric-coated tablets, and the patients in the observation group were given rabeprazole sodium enteric-coated capsules. The clinical efficacy, serum levels of GAS and et, the eradication rate of Helicobacter pylori and the incidence of adverse reactions were compared between the two groups. Results the clinical effect of the observation group was better than that of the control group (P 0.05). Before treatment, there was no significant difference in serum GAS and et levels between the two groups. After treatment, the serum GAS level in the observation group was higher than that in the control group, and the serum et level in the observation group was lower than that in the control group (P 0.05). The eradication rate of Helicobacter pylori in the observation group was higher than that in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion Rabeprazole is safe and effective in the treatment of CAG. It can significantly increase the level of serum GAS and decrease the level of et.
【作者单位】：河南省信阳市中心医院;
【分类号】：R573.32

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